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Evaluation of leaf extracts of Moringa oleifera Lam. On testosterone enanthate-induced polycystic ovary syndrome (PCOS) in mice

2025-01-01Artigo de investigação Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorKhalid, Shakeela
dc.contributor.authorArshad, Muhammad
dc.contributor.authorSiddque, Farzana
dc.contributor.authorArshad, Muhammad Sajid
dc.contributor.authorSajid, Marina
dc.contributor.authorKhalid, Waseem
dc.contributor.authorAziz, Zaira
dc.contributor.authorKhalid, Muhammad Zubair
dc.contributor.authorAlharbi, Sulaiman Ali
dc.contributor.authorAnsari, Mohammad Javed
dc.contributor.authorZinedine, Abdellah
dc.contributor.authorBartkiene, Elena
dc.contributor.authorRocha, João Miguel
dc.date.accessioned2025-09-08T08:27:50Z
dc.date.available2025-09-08T08:27:50Z
dc.date.issued2025-01-01
dc.description.abstractPolycystic ovary syndrome (PCOS) is a multifactorial endocrinological and metabolic disorder that affects women of reproductive age. It is often associated with hyperandrogenism, obesity, anovulation, infertility and insulin resistance. In this study, the imminent efficacy of MoLP (Moringa oleifera leaf powder) and MoLE (M. oleifera leaf extract) in treating PCOS in female albino mice was explored. Female albino mice were injected with testosterone enanthate [1.0 mg/100 g body weight (b.w.)] for 35-days to induce PCOS. For the treatment, mice were administered with M. oleifera leaf powder (250 and 500 mg/kg b.w.), M. oleifera leaf extract (250 and 500 mg/kg b.w.), and metformin (250 mg/kg b.w.) for 14 days. Following the intervention, body weight, blood glucose, c-peptide, testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels and stages of the estrus cycle were measured at 0, 7 and 14 days. The ovaries were examined stereologically to determine the number and diameter of follicles. Results indicated that MoLP, MoLE (500 mg/kg b.w.) and metformin (250 mg/kg b.w.) significantly decreased body weight, blood glucose, c-peptide, testosterone and LH levels while increasing FSH levels and ovary weight over time compared to PCOS-induced mice. Additionally, regulation of the estrus cycle and folliculogenesis in PCOS-induced mice was observed. Overall, the present study revealed that M. oleifera may have the potential as a therapeutic intervention for PCOS.eng
dc.identifier.citationKhalid, S., Arshad, M., Siddque, F., & Arshad, M. S. et al. (in press). Evaluation of leaf extracts of Moringa oleifera Lam. On testosterone enanthate-induced polycystic ovary syndrome (PCOS) in mice. Advances in Traditional Medicine. https://doi.org/10.1007/s13596-025-00843-9
dc.identifier.doi10.1007/s13596-025-00843-9
dc.identifier.eid105012400902
dc.identifier.issn2662-4052
dc.identifier.other654a9230-e0d6-4ca2-bae0-72bb14eedc72
dc.identifier.urihttp://hdl.handle.net/10400.14/54705
dc.identifier.wos001541694200001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMetformin
dc.subjectMoringa oleifera
dc.subjectMus musculus
dc.subjectPolycystic ovary syndrome (PCOS)
dc.subjectTestosterone enanthate
dc.titleEvaluation of leaf extracts of Moringa oleifera Lam. On testosterone enanthate-induced polycystic ovary syndrome (PCOS) in miceeng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleAdvances in Traditional Medicine
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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