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Bone formation and resorption markers at 7 years of age: relations with growth and bone mineralization

2019Journal article Open access
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dc.contributor.authorMonjardino, Teresa
dc.contributor.authorSilva, Poliana
dc.contributor.authorAmaro, Joana
dc.contributor.authorCarvalho, Ofélia
dc.contributor.authorGuimarães, João Tiago
dc.contributor.authorSantos, Ana Cristina
dc.contributor.authorLucas, Raquel
dc.date.accessioned2020-03-11T15:01:44Z
dc.date.available2020-03-11T15:01:44Z
dc.date.issued2019
dc.description.abstractPurpose We aimed to describe bone formation and resorption markers in generally healthy prepubertal children using total alkaline phosphatase (tALP), osteocalcin (OC) and β-isomerized C-terminal telopeptides of type I collagen (β-CTx) serum concentrations and to estimate markers’ correlations with anthropometric growth (height, weight, body mass index and trajectories of weight gain) as well as bone mineral content (BMC) and areal density (aBMD). Methods We assessed 395 7-year-old children from the Generation XXI cohort with tALP, OC and β-CTx concentrations determined from a fasting venous blood sample and BMC/aBMD measured by dual-energy X-ray absorptiometry. Gender-specific reference intervals for tALP, OC and β-CTx in 7-year-old children were established by calculating the 2.5th and 97.5th percentiles. Pearson and partial correlation coefficients (controlling for sex, age, body size and season) between bone markers and growth measures were computed. Results tALP increased with height (rpartial controlled for sex = 0.26, 95%CI: 0.17, 0.35), was higher in overweight than in healthy weight children, and in children who gained weight above average during infancy. No correlations were found between OC or β-CTx and growth. In girls, OC was slightly correlated with subtotal BMC (rpartial = 0.22, 95%CI: 0.08, 0.35), subtotal aBMD (rpartial = 0.20, 95%CI: 0.06, 0.33) and lumbar spine aBMD (rpartial = 0.23, 95%CI: 0.09, 0.36). tALP and β-CTx were not correlated with any of the DXA-derived bone measures. Conclusion This study contributed to the description of bone turnover at 7 years of age and suggested that bone metabolism markers measured in a single point in time have limited ability to describe anthropometric growth and overall bone status in generally healthy prepubertal children.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMonjardino, T., Silva, P., Amaro, J., Carvalho, O., Guimaraes, J. T., Santos, A. C., Lucas, R. (2019). Bone formation and resorption markers at 7 years of age: relations with growth and bone mineralization. PloS one, 14(8): e0219423pt_PT
dc.identifier.doi10.1371/journal.pone.0219423pt_PT
dc.identifier.eid85071118143
dc.identifier.issn1932-6203
dc.identifier.pmcPMC6705799
dc.identifier.pmid31437153
dc.identifier.urihttp://hdl.handle.net/10400.14/29903
dc.identifier.wos000485036900006
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLoSpt_PT
dc.relationPOCI-01-0145-FEDER-016838pt_PT
dc.relationPOCI-01-0145-FEDER-016837pt_PT
dc.relationPathways from early life to cardiometabolic risk during childhood
dc.relationPOCI-01-0145-FEDER-006862pt_PT
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationIDENTIFYING SENSITIVE PERIODS FOR THE EFFECTS OF ADIPOSITY AND GLUCOSE METABOLISM ON PEDIATRIC BONE: A BIRTH COHORT APPROACH
dc.relationPOCI-01-0145-FEDER-029087pt_PT
dc.relationPTDC/SAU-EPI/ 29087/2017pt_PT
dc.relationLife-course biological pathways underlying the early development of obesity
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleBone formation and resorption markers at 7 years of age: relations with growth and bone mineralizationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePathways from early life to cardiometabolic risk during childhood
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleIDENTIFYING SENSITIVE PERIODS FOR THE EFFECTS OF ADIPOSITY AND GLUCOSE METABOLISM ON PEDIATRIC BONE: A BIRTH COHORT APPROACH
oaire.awardTitleLife-course biological pathways underlying the early development of obesity
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FDTP-EPI%2F1687%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FDTP-EPI%2F3306%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/EXPL%2FDTP-EPI%2F0280%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04750%2F2019/PT
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oaire.citation.issue8pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamCOMPETE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
oaire.fundingStreamInvestigador FCT
person.familyNameMonjardino
person.familyNameSilva
person.familyNameSantos
person.familyNameLucas
person.givenNameTeresa
person.givenNamePoliana
person.givenNameAna
person.givenNameRaquel
person.identifier.ciencia-idFE17-375E-777F
person.identifier.ciencia-id9B11-7EB3-5B12
person.identifier.ciencia-id2619-1EDB-55DF
person.identifier.ciencia-id8414-FB8B-8C68
person.identifier.orcid0000-0003-4944-3366
person.identifier.orcid0000-0003-3164-272X
person.identifier.orcid0000-0002-2992-5299
person.identifier.orcid0000-0002-4408-8134
person.identifier.scopus-author-id57199965799
person.identifier.scopus-author-id55712944800
person.identifier.scopus-author-id12141781700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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