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Development of composite scaffolds based on cerium doped-hydroxyapatite and natural gums-biological and mechanical properties

2019Journal article Open access
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dc.contributor.authorSantos, Marcus Vinicius Beserra dos
dc.contributor.authorRocha, Lorenna Bastos Nogueira
dc.contributor.authorVieira, Ewerton Gomes
dc.contributor.authorOliveira, Ana Leite
dc.contributor.authorLobo, Anderson Oliveira
dc.contributor.authorCarvalho, Maria Acelina Martins de
dc.contributor.authorOsajima, Josy Anteveli
dc.contributor.authorSilva-Filho, Edson Cavalcanti
dc.date.accessioned2019-08-09T13:48:50Z
dc.date.available2019-08-09T13:48:50Z
dc.date.issued2019
dc.description.abstractHydroxyapatite (HAp) is a ceramic material composing the inorganic portion of bones. Ionic substitutions enhance characteristics of HAp, for example, calcium ions (Ca2+) by cerium ions (Ce3+). The use of HAp is potentialized through biopolymers, cashew gum (CG), and gellan gum (GG), since CG/GG is structuring agents in the modeling of structured biocomposites, scaffolds. Ce-HApCG biocomposite was synthesized using a chemical precipitation method. The obtained material was frozen (–20 °C for 24 h), and then vacuum dried for 24 h. The Ce-HApCG was characterized by X-Ray diffractograms (XRD), X-ray photoemission spectra (XPS), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), and energy dispersive spectroscopy (EDS). XRD and FTIR showed that Ce-HApCG was successfully synthesized. XRD showed characteristic peaks at 2θ = 25.87 and 32.05, corresponding to the crystalline planes (0 0 2) and (2 1 1), respectively, while phosphate bands were present at 1050 cm−1 and 1098 cm−1, indicating the success of composite synthesis. FESEM showed pores and incorporated nanostructured granules of Ce-HApCG. The mechanical test identified that Ce-HApCG has a compressive strength similar to the cancellous bone’s strength and some allografts used in surgical procedures. In vitro tests (MTT assay and hemolysis) showed that scaffold was non-toxic and exhibited low hemolytic activity. Thus, the Ce-HApCG has potential for application in bone tissue engineering.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVinicius Beserra dos Santos, M., Bastos Nogueira Rocha, L., Gomes Vieira, E., Leite Oliveira, A., Oliveira Lobo, A., de Carvalho, M. A. M., … Cavalcanti Silva-Filho, E. (2019). Development of Composite Scaffolds Based on Cerium Doped-Hydroxyapatite and Natural Gums—Biological and Mechanical Properties. Materials, 12(15), 2389. https://doi.org/10.3390/ma12152389pt_PT
dc.identifier.doi10.3390/ma12152389pt_PT
dc.identifier.eid85070408849
dc.identifier.eissn1996-1944
dc.identifier.pmcPMC6695794
dc.identifier.pmid31357470
dc.identifier.urihttp://hdl.handle.net/10400.14/28135
dc.identifier.wos000482576900050
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation307460/2016-9
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCalcium phosphatept_PT
dc.subjectDopingpt_PT
dc.subjectScaffoldpt_PT
dc.titleDevelopment of composite scaffolds based on cerium doped-hydroxyapatite and natural gums-biological and mechanical propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue15
oaire.citation.titleMaterialspt_PT
oaire.citation.volume12
person.familyNameOliveira
person.familyNameLobo
person.familyNameOsajima
person.familyNameSilva Filho
person.givenNameAna
person.givenNameAnderson
person.givenNameJosy
person.givenNameEdson
person.identifier1415634
person.identifier114239
person.identifier760930
person.identifier.ciencia-id4713-31C8-A356
person.identifier.orcid0000-0001-8012-4203
person.identifier.orcid0000-0002-2544-0438
person.identifier.orcid0000-0001-7089-3244
person.identifier.orcid0000-0003-0988-2970
person.identifier.ridJ-3404-2013
person.identifier.ridB-2893-2011
person.identifier.ridD-6401-2013
person.identifier.scopus-author-id55937245800
person.identifier.scopus-author-id14019685200
person.identifier.scopus-author-id16507501000
person.identifier.scopus-author-id6508173867
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication87934068-f621-402f-b5e6-93e492526ced
relation.isAuthorOfPublication071853e4-9c15-4549-a681-e7edd44fb6f4
relation.isAuthorOfPublication71007aa5-8a12-488f-9610-273b45cc5741
relation.isAuthorOfPublication4fe5877b-0511-4fbb-9a1d-e7b78c313921
relation.isAuthorOfPublication.latestForDiscovery87934068-f621-402f-b5e6-93e492526ced

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