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Sex and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomography

2023-09-01Journal article Open access
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dc.contributor.authorRosendael, Sophie E. Van
dc.contributor.authorBax, A. Maxim
dc.contributor.authorLin, Fay Y.
dc.contributor.authorAchenbach, Stephan
dc.contributor.authorAndreini, Daniele
dc.contributor.authorBudoff, Matthew J.
dc.contributor.authorCademartiri, Filippo
dc.contributor.authorCallister, Tracy Q.
dc.contributor.authorChinnaiyan, Kavitha
dc.contributor.authorChow, Benjamin J. W.
dc.contributor.authorCury, Ricardo C.
dc.contributor.authorDeLago, Augustin J.
dc.contributor.authorFeuchtner, Gudrun
dc.contributor.authorHadamitzky, Martin
dc.contributor.authorHausleiter, Joerg
dc.contributor.authorKaufmann, Philipp A.
dc.contributor.authorKim, Yong Jin
dc.contributor.authorLeipsic, Jonathon A.
dc.contributor.authorMaffei, Erica
dc.contributor.authorMarques, Hugo
dc.contributor.authorGonçalves, Pedro de Araújo
dc.contributor.authorPontone, Gianluca
dc.contributor.authorRaff, Gilbert L.
dc.contributor.authorRubinshtein, Ronen
dc.contributor.authorVillines, Todd C.
dc.contributor.authorChang, Hyuk Jae
dc.contributor.authorBerman, Daniel S.
dc.contributor.authorMin, James K.
dc.contributor.authorBax, Jeroen J.
dc.contributor.authorShaw, Leslee J.
dc.contributor.authorRosendael, Alexander R. Van
dc.date.accessioned2024-01-03T17:27:42Z
dc.date.available2024-01-03T17:27:42Z
dc.date.issued2023-09-01
dc.description.abstractAims: The totality of atherosclerotic plaque derived from coronary computed tomography angiography (CCTA) emerges as a comprehensive measure to assess the intensity of medical treatment that patients need. This study examines the differences in age onset and prognostic significance of atherosclerotic plaque burden between sexes. Methods and results: From a large multi-center CCTA registry the Leiden CCTA score was calculated in 24 950 individuals. A total of 11 678 women (58.5 ± 12.4 years) and 13 272 men (55.6 ± 12.5 years) were followed for 3.7 years for major adverse cardiovascular events (MACE) (death or myocardial infarction). The age where the median risk score was above zero was 12 years higher in women vs. men (64-68 years vs. 52-56 years, respectively, P < 0.001). The Leiden CCTA risk score was independently associated with MACE: score 6-20: HR 2.29 (1.69-3.10); score > 20: HR 6.71 (4.36-10.32) in women, and score 6-20: HR 1.64 (1.29-2.08); score > 20: HR 2.38 (1.73-3.29) in men. The risk was significantly higher for women within the highest score group (adjusted P-interaction = 0.003). In pre-menopausal women, the risk score was equally predictive and comparable with men. In post-menopausal women, the prognostic value was higher for women [score 6-20: HR 2.21 (1.57-3.11); score > 20: HR 6.11 (3.84-9.70) in women; score 6-20: HR 1.57 (1.19-2.09); score > 20: HR 2.25 (1.58-3.22) in men], with a significant interaction for the highest risk group (adjusted P-interaction = 0.004). Conclusion: Women developed coronary atherosclerosis approximately 12 years later than men. Post-menopausal women within the highest atherosclerotic burden group were at significantly higher risk for MACE than their male counterparts, which may have implications for the medical treatment intensity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1093/ehjci/jead094pt_PT
dc.identifier.eid85168778722
dc.identifier.issn2047-2404
dc.identifier.pmcPMC10445263
dc.identifier.pmid37165981
dc.identifier.urihttp://hdl.handle.net/10400.14/43473
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectCoronary artery diseasept_PT
dc.subjectCoronary computed tomography angiography (CCTA)pt_PT
dc.subjectPrognosispt_PT
dc.subjectSex differencespt_PT
dc.titleSex and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomographypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1189pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1180pt_PT
oaire.citation.titleEuropean Heart Journal Cardiovascular Imagingpt_PT
oaire.citation.volume24pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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