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Integrated analyses of the transmission history of SARS-CoV-2 and its association with molecular evolution of the virus underlining the pandemic outbreaks in Italy, 2019-2023

2024-12Journal article Open access
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dc.contributor.authorCella, Eleonora
dc.contributor.authorFonseca, Vagner
dc.contributor.authorBranda, Francesco
dc.contributor.authorTosta, Stephane
dc.contributor.authorMoreno, Keldenn
dc.contributor.authorSchuab, Gabriel
dc.contributor.authorAli, Sobur
dc.contributor.authorSlavov, Svetoslav Nanev
dc.contributor.authorScarpa, Fabio
dc.contributor.authorSantos, Luciane Amorim
dc.contributor.authorKashima, Simone
dc.contributor.authorWilkinson, Eduan
dc.contributor.authorTegally, Houriiyah
dc.contributor.authorMavian, Carla
dc.contributor.authorBorsetti, Alessandra
dc.contributor.authorCaccuri, Francesca
dc.contributor.authorSalemi, Marco
dc.contributor.authorOliveira, Tulio de
dc.contributor.authorAzarian, Taj
dc.contributor.authorFilippis, Ana Maria Bispo de
dc.contributor.authorAlcantara, Luiz Carlos Junior
dc.contributor.authorCeccarelli, Giancarlo
dc.contributor.authorCaruso, Arnaldo
dc.contributor.authorColizzi, Vittorio
dc.contributor.authorMarcello, Alessandro
dc.contributor.authorLourenço, José
dc.contributor.authorCiccozzi, Massimo
dc.contributor.authorGiovanetti, Marta
dc.date.accessioned2024-11-13T15:53:59Z
dc.date.available2024-11-13T15:53:59Z
dc.date.issued2024-12
dc.description.abstractBackground: Italy was significantly affected by the COVID-19 pandemic, experiencing multiple waves of infection following the sequential emergence of new variants. Understanding the transmission patterns and evolution of SARS-CoV-2 is vital for future preparedness. Methods: We conducted an analysis of viral genome sequences, integrating epidemiological and phylodynamic approaches, to characterize how SARS-CoV-2 variants have spread within the country. Results: Our findings indicate bidirectional international transmission, with Italy transitioning between importing and exporting the virus. Italy experienced four distinct epidemic waves, each associated with a significant reduction in fatalities from 2021 to 2023. These waves were primarily driven by the emergence of VOCs such as Alpha, Delta, and Omicron, which were reflected in observed transmission dynamics and effectiveness of public health measures. Conclusions: The changing patterns of viral spread and variant prevalence throughout Italy's pandemic response underscore the continued importance of flexible public health strategies and genomic surveillance, both of which are crucial for tracking the evolution of variants and adapting control measures effectively to ensure preparedness for future outbreaks.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijid.2024.107262pt_PT
dc.identifier.eid85208104786
dc.identifier.issn1201-9712
dc.identifier.pmid39389289
dc.identifier.urihttp://hdl.handle.net/10400.14/47204
dc.identifier.wos001355583000001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectD614G variantpt_PT
dc.subjectGenomic epidemiologypt_PT
dc.subjectItalypt_PT
dc.subjectPandemicpt_PT
dc.subjectSARS-CoV-2pt_PT
dc.titleIntegrated analyses of the transmission history of SARS-CoV-2 and its association with molecular evolution of the virus underlining the pandemic outbreaks in Italy, 2019-2023pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleInternational Journal of Infectious Diseasespt_PT
oaire.citation.volume149pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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