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Orientador(es)
Resumo(s)
Research efforts on the production of chitosan nanoparticles (NP) as delivery systems of bioactive
compounds such as polyphenols have been made along the last decade. Nevertheless, the effect of the
phenolic compound structure in the production of these NP was never evaluated so far. Low and high
molecular weights chitosan (LMWC and HMWC) NP loaded with the phenolic acids, protocatechuic (PA)
and 2,5-dihydroxybenzoic acids (2,5-DHBA) were produced by ionic gelation. Antioxidant activities were
determined by ORAC assay. Physical and thermal properties were evaluated by dynamic light scattering
(DLS) and differential scanning calorimetry (DSC), respectively. Stability and release of phenolic acids
during simulation of gastrointestinal tract (GIT) conditions were also assessed. Nanoparticles sizes
ranged from 300 to 600 nm and maintained stable during storage at 4 C during 30 d. Antioxidant activities
of the phenolic acids decreased when loaded in the NP. High molecular weight chitosan NP
adsorbed higher energy and melted at lower temperatures than LMWC NP. Nanoparticles produced with
HMWC released higher phenolic acids % at GIT simulated conditions and with slight increases in their
sizes. The most proper systems for delivery of PA and 2,5-DHBA were found to be LMWC and HMWC NP,
respectively. These NP could be used to as functional food ingredients or as models for production of
phenolic acids-rich extracts NP for future incorporation in food matrices.
Descrição
Palavras-chave
Chitosan Nanoparticles Phenolic compounds Gastrointestinal tract
Contexto Educativo
Citação
MADUREIRA, Ana Raquel; PEREIRA, Adriana; PINTADO, M. E. - Chitosan nanoparticles loaded with 2,5-dihydroxybenzoic acid and protocatechuic acid: Properties and digestion. Journal of Food Engineering. ISSN 0260-8774. Vol. 174 (2016), p. 8-14