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Sterile and dual-porous aerogels scaffolds obtained through a multistep supercritical CO2-based approach

2019Journal article Open access
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dc.contributor.authorSantos-Rosales, Víctor
dc.contributor.authorArdao, Inés
dc.contributor.authorAlvarez-Lorenzo, Carmen
dc.contributor.authorRibeiro, Nilza
dc.contributor.authorOliveira, Ana L.
dc.contributor.authorGarcía-González, Carlos A.
dc.date.accessioned2019-03-13T15:07:27Z
dc.date.available2019-03-13T15:07:27Z
dc.date.issued2019
dc.description.abstractAerogels from natural polymers are endowed with attractive textural and biological properties for biomedical applications due to their high open mesoporosity, low density, and reduced toxicity. Nevertheless, the lack of macroporosity in the aerogel structure and of a sterilization method suitable for these materials restrict their use for regenerative medicine purposes and prompt the research on getting ready-to-implant dual (macro + meso)porous aerogels. In this work, zein, a family of proteins present in materials for tissue engineering, was evaluated as a sacrificial porogen to obtain macroporous starch aerogels. This approach was particularly advantageous since it could be integrated in the conventional aerogel processing method without extra leaching steps. Physicochemical, morphological, and mechanical characterization were performed to study the effect of porogen zein at various proportions (0:1, 1:2, and 1:1 zein: starch weight ratio) on the properties of the obtained starch-based aerogels. From a forward-looking perspective for its clinical application, a supercritical CO2 sterilization treatment was implemented for these aerogels. The sterilization efficacy and the influence of the treatment on the aerogel final properties were evaluated mainly in terms of absence of microbial growth, cytocompatibility, as well as physicochemical, structural, and mechanical modifications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos-Rosales, V., Ardao, I., Alvarez-Lorenzo, C., Ribeiro, N., Oliveira, A., & García-González, C. (2019). Sterile and Dual-Porous Aerogels Scaffolds Obtained through a Multistep Supercritical CO2-Based Approach. Molecules, 24(5), 871. https://doi.org/10.3390/molecules24050871pt_PT
dc.identifier.doi10.3390/molecules24050871pt_PT
dc.identifier.eid85062889223
dc.identifier.issn1420-3049
dc.identifier.pmcPMC6429194
dc.identifier.pmid30823685
dc.identifier.urihttp://hdl.handle.net/10400.14/27085
dc.identifier.wos000462662900047
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCA18125
dc.relationIF/00411/2013/CP1167
dc.relationIF/00411/2013
dc.relationED431F 2016/010
dc.relationED431C 2016/008
dc.relationSAF2017-83118-R
dc.relationRYC2014-15239
dc.relation0245_IBEROS_1_E
dc.relationED481A-2018/014
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectStarch aerogelspt_PT
dc.subjectZeinpt_PT
dc.subjectSupercritical sterilizationpt_PT
dc.subjectSupercritical CO2pt_PT
dc.subjectRegenerative medicinept_PT
dc.titleSterile and dual-porous aerogels scaffolds obtained through a multistep supercritical CO2-based approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.citation.titleMoleculespt_PT
oaire.fundingStream5876
person.familyNameArdao
person.familyNameAlvarez-Lorenzo
person.familyNameRibeiro
person.familyNameOliveira
person.familyNameGarcía-González
person.givenNameInés
person.givenNameCarmen
person.givenNameNilza
person.givenNameAna
person.givenNameCarlos A
person.identifier1415634
person.identifier.ciencia-idF31D-5595-860E
person.identifier.ciencia-id4713-31C8-A356
person.identifier.ciencia-id9D16-C1D8-7567
person.identifier.orcid0000-0002-1201-4165
person.identifier.orcid0000-0002-8546-7085
person.identifier.orcid0000-0002-9975-5432
person.identifier.orcid0000-0001-8012-4203
person.identifier.orcid0000-0001-9542-3679
person.identifier.ridJ-8101-2014
person.identifier.ridJ-3404-2013
person.identifier.ridK-2130-2014
person.identifier.scopus-author-id7004396916
person.identifier.scopus-author-id24333106700
person.identifier.scopus-author-id55937245800
person.identifier.scopus-author-id26539915200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication114080e8-7f6f-4767-b597-580e6b06377d
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relation.isAuthorOfPublication.latestForDiscoveryf33e534a-29ad-4b38-8494-b52d92e58624
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