Repository logo
 
Publication

Silica microparticles from sugarcane by-products as an encapsulation system for retinoids aimed at topical sustained release

2024-03Journal article Open access
Simple item page
dc.contributor.authorCosta, Joana R.
dc.contributor.authorCosta, Ana Helena
dc.contributor.authorAzevedo-Silva, João
dc.contributor.authorTavares-Valente, Diana
dc.contributor.authorSousa, Sérgio C.
dc.contributor.authorNeto, Tânia
dc.contributor.authorPintado, Manuela E.
dc.contributor.authorMadureira, Ana Raquel
dc.date.accessioned2024-04-08T13:59:45Z
dc.date.available2024-04-08T13:59:45Z
dc.date.issued2024-03
dc.description.abstractThe encapsulation of retinol within silica microparticles has emerged as a promising opportunity in the realm of cosmetic and pharmaceutical formulations, driven by the need to reinforce the photoprotection and oxidation stability of retinol. This work examines the process of encapsulating retinol into silica microparticles. The association efficiency, microparticle size, molecular structure, morphology, oxidation, and release profile, as well as biocompatibility and skin sensitization, were evaluated. Results showed that 0.03% of retinol and 9% of emulsifier leads to an association efficiency higher than 99% and a particle size with an average of 5.2 µm. FTIR results indicate that there is an association of retinol with the silica microparticles, and some may be on the surface. Microscopy indicates that when association happens, there is less aggregation of the particles. Oxidation occurs in two different phases, the first related to the retinol on the surface and the second to the associated retinol. In addition, a burst release of up to 3 h (30% free retinol, 17% associated retinol) was observed, as well as a sustained release of 44% of retinol up to 24 h. Encapsulation allowed an increase in the minimal skin cytotoxic concentrations of retinol from 0.04 μg/mL to 1.25 mg/mL without skin sensitization. Overall, retinol is protected when associated with silica microparticles, being safe to use in cosmetics and dermatology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijms25063215pt_PT
dc.identifier.eid85189009087
dc.identifier.issn1661-6596
dc.identifier.pmcPMC10970169
dc.identifier.pmid38542189
dc.identifier.urihttp://hdl.handle.net/10400.14/44466
dc.identifier.wos001192808600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectControl releasept_PT
dc.subjectResponse surface methodologypt_PT
dc.subjectRetinolpt_PT
dc.subjectSilica microparticlespt_PT
dc.subjectTopical deliverypt_PT
dc.titleSilica microparticles from sugarcane by-products as an encapsulation system for retinoids aimed at topical sustained releasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume25pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
96747534.pdf
Size:
11.99 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.44 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CBQF - Contribuições em Revistas Científicas / Contribution to Journals