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Aquaporin-1 sustains lymphangiogenic responses in hyperosmotic inflammatory microenvironments

2026-07-06Artigo de investigação Acesso aberto
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dc.contributor.authorRoci, Irena
dc.contributor.authorKim, Jaeryung
dc.contributor.authorKorodi, Kelly de
dc.contributor.authorWyss, Tania
dc.contributor.authorBernier-Latmani, Jeremiah
dc.contributor.authorArroz-Madeira, Silvia
dc.contributor.authorGonzález-Loyola, Alejandra
dc.contributor.authorBovay, Esther
dc.contributor.authorGrenningloh, Nadia
dc.contributor.authorSchoofs, Hans
dc.contributor.authorJeon, Noo Li
dc.contributor.authorGiampietro, Costanza
dc.contributor.authorMäkinen, Taija
dc.contributor.authorNoël, Agnès
dc.contributor.authorPetrova, Tatiana V.
dc.date.accessioned2026-06-23T16:11:02Z
dc.date.available2026-06-23T16:11:02Z
dc.date.issued2026-07-06
dc.description.abstractIntestinal lymphatic vessels are essential for dietary lipid absorption and immune cell trafficking. Villus lymphatic capillaries, lacteals, undergo continuous VEGF-C–dependent renewal to function in a hyperosmolar, inflammatory environment exposed to dietary and microbial by-products. To define mechanisms underlying this adaptation, we integrated new and published single-cell RNA-sequencing datasets of murine small intestinal lymphatic endothelial cells (LECs). Lacteal LECs resembled Ptx3+ immune-interacting LECs and were characterized by high expression of water channel AQP1. LEC-specific Aqp1 deletion reduced lacteal length, impaired lipid uptake, and limited weight gain on a high-fat diet, while mosaic deletion revealed a cell-autonomous requirement for AQP1 in LEC positioning at hyperosmolar tip regions. AQP1 promoted LEC migration under hyperosmotic stress by preserving cytoskeletal and junctional remodeling and alleviating osmotic stress–induced transcriptional programs. AQP1 was upregulated during inflammatory remodeling in lymphedema and lymphatic malformations, but not during embryonic lymphangiogenesis. These findings link lacteal regeneration to inflammatory lymphatic remodeling and highlight tissue osmolarity as a biophysical determinant of postnatal lymphangiogenesis.eng
dc.identifier.doi10.1084/jem.20250506
dc.identifier.eid105040895021
dc.identifier.otherbde0d1ea-79b3-4611-bd64-8ac6de7e475b
dc.identifier.pmid42223480
dc.identifier.urihttp://hdl.handle.net/10400.14/58224
dc.identifier.wos001780696400001
dc.language.isoeng
dc.peerreviewedyes
dc.publisherRockefeller University Press
dc.rights.uriN/A
dc.titleAquaporin-1 sustains lymphangiogenic responses in hyperosmotic inflammatory microenvironments
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue7
oaire.citation.volume223
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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