Repository logo
 
Publication

CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types

2023-12Journal article Open access
Simple item page
dc.contributor.authorBarros, Leandro
dc.contributor.authorPiontkivska, Daryna
dc.contributor.authorFigueiredo-Campos, Patrícia
dc.contributor.authorFanczal, Júlia
dc.contributor.authorRibeiro, Sofia Pereira
dc.contributor.authorBaptista, Marta
dc.contributor.authorAriotti, Silvia
dc.contributor.authorSantos, Nuno
dc.contributor.authorAmorim, Maria João
dc.contributor.authorPereira, Cristina Silva
dc.contributor.authorVeldhoen, Marc
dc.contributor.authorFerreira, Cristina
dc.date.accessioned2023-10-04T13:43:17Z
dc.date.available2023-10-04T13:43:17Z
dc.date.issued2023-12
dc.description.abstractImmunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ memory T cells develop at the location of infection: tissue-resident memory T cells (TRM). CD8+ T-cell responses are associated with type-1 infections and type-1 regulatory T cells (TREG) are important for CD8+ T-cell development, however, if CD8+ TRM cells develop under other infection types and require immune type-specific TREG cells is unknown. We used three distinct lung infection models, to show that type-2 helminth infection does not establish CD8+ TRM cells. Intracellular (type-1) and extracellular (type-3) infections do and rely on the recruitment of response type-matching TREG population contributing transforming growth factor-β. Nevertheless, type-1 TREG cells remain the most important population for TRM cell development. Once established, TRM cells maintain their immune type profile. These results may have implications in the development of vaccines inducing CD8+ TRM cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1038/s41467-023-41364-wpt_PT
dc.identifier.eid85170632511
dc.identifier.issn2041-1723
dc.identifier.pmcPMC10495327
dc.identifier.pmid37696824
dc.identifier.source-work-id491A-6426-F006/3346542
dc.identifier.urihttp://hdl.handle.net/10400.14/42766
dc.identifier.wos001157889300021
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleCD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell typespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleNature Communicationspt_PT
oaire.citation.volume14pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
75219074.pdf
Size:
3.06 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.44 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CBR - Contribuições em Revistas Científicas / Contribution to Journals