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Experimental design and methodological approaches used to assess the potential of essential oils in wound healing
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Wound healing (WH) remains a complex clinical challenge, driving the search for effective therapeutic alternatives such as essential oils (EOs) derived from medicinal plants. However, the reliability and translational relevance of findings in this field are highly dependent on the methodological approaches used to assess EO efficacy. Diverse in vitro and in vivo models, alongside varying experimental protocols, have been employed, often leading to inconsistent or non-comparable outcomes. In this review, we critically examine these methodologies, highlighting their strengths, limitations, and impact on interpreting WH activity. By emphasizing the need for standardized and robust evaluation strategies, we aim to guide future research toward more reliable and reproducible assessments of EOs in wound healing. Furthermore, some details on the WH process and the chemistry of EOs are provided. To gather relevant data, several databases were utilized, including Google Scholar, ScienceDirect, Web of Science, Scopus, and PubMed. The literature revealed that many test are used in vivo and in vivo to assess the WH effect of EOs, including Incision, excision, burns, scratch and microfluidic assay. Other tests such as human model are not usually employed for EOs but there are some on data on plants extracts. Interestingly, this review provides some significant discussing on the approaches used to evaluate the WH activity of EOs and can be taking as a strong scientific basic for the future research in this field.
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Wound healing Essential oils Methods Approaches In vivo In vitro