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The Health-Promoting Potential of Salix spp. Bark Polar Extracts: Key Insights on Phenolic Composition and In Vitro Bioactivity and Biocompatibility

2019Journal article Open access
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dc.contributor.authorRamos, Patrícia A. B.
dc.contributor.authorMoreirinha, Catarina
dc.contributor.authorSilva, Sara
dc.contributor.authorCosta, Eduardo M.
dc.contributor.authorVeiga, Mariana
dc.contributor.authorCoscueta, Ezequiel R.
dc.contributor.authorSantos, Sónia A. O.
dc.contributor.authorAlmeida, Adelaide
dc.contributor.authorPintado, M. Manuela
dc.contributor.authorFreire, Carmen S. R.
dc.contributor.authorSilva, Artur M. S.
dc.contributor.authorSilvestre, Armano J. D.
dc.date.accessioned2020-01-07T18:59:11Z
dc.date.available2020-01-07T18:59:11Z
dc.date.issued2019
dc.description.abstractSalix spp. have been exploited for energy generation, along with folk medicine use of bark extracts for antipyretic and analgesic benefits. Bark phenolic components, rather than salicin, have demonstrated interesting bioactivities, which may ensure the sustainable bioprospection of Salix bark. Therefore, this study highlights the detailed phenolic characterization, as well as the in vitro antioxidant, anti-hypertensive, Staphylococcus aureus growth inhibitory effects, and biocompatibility of Salix atrocinerea Brot., Salix fragilis L., and Salix viminalis L. bark polar extracts. Fifteen phenolic compounds were characterized by ultra-high-performance liquid chromatography-ultraviolet detection-mass spectrometry analysis, from which two flavan-3-ols, an acetophenone, five flavanones, and a flavonol were detected, for the first time, as their bark components. Salix bark extracts demonstrated strong free radical scavenging activity (5.58–23.62 µg mL−1 IC50 range), effective inhibition on angiotensin-I converting enzyme (58–84%), and S. aureus bactericidal action at 1250–2500 µg mL−1 (6–8 log CFU mL−1 reduction range). All tested Salix bark extracts did not show cytotoxic potential against Caco-2 cells, as well as S. atrocinerea Brot. and S. fragilis L. extracts at 625 and 1250 µg mL−1 against HaCaT and L929 cells. These valuable findings can pave innovative and safer food, nutraceutical, and/or cosmetic applications of Salix bark phenolic-containing fractions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRamos, P. A., Moreirinha, C., Silva, S., Costa, E. M., Veiga, M., Coscueta, E., ... Silva, A. (2019). The Health-Promoting Potential of Salix spp. Bark polar extracts: key insights on phenolic composition and in vitro bioactivity and biocompatibility. Antioxidants, 8(12), 609pt_PT
dc.identifier.doi10.3390/antiox8120609pt_PT
dc.identifier.eid85075927914
dc.identifier.issn2076-3921
dc.identifier.pmcPMC6943414
dc.identifier.pmid31801290
dc.identifier.urihttp://hdl.handle.net/10400.14/29108
dc.identifier.wos000506633000042
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUID/MAR/LA0017/2019pt_PT
dc.relationCICECO-Aveiro Institute of Materials
dc.relationOrganic Chemistry, Natural Products and Food Stuffs
dc.relationCentre for Biotechnology and Fine Chemistry
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSalix spp. bark polar extractspt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectAnti-hypertensive potentialpt_PT
dc.subjectAntibacterial e_ectpt_PT
dc.subjectBioeconomy-based value chainpt_PT
dc.titleThe Health-Promoting Potential of Salix spp. Bark Polar Extracts: Key Insights on Phenolic Composition and In Vitro Bioactivity and Biocompatibilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardTitleOrganic Chemistry, Natural Products and Food Stuffs
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FCTM%2F50011%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00062%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00464%2F2017%2FCP1459%2FCT0033/PT
oaire.citation.issue12pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume8pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2017
person.familyNameRamos Portela
person.familyNameSilva
person.familyNameCosta
person.familyNameVeiga
person.familyNameCoscueta
person.familyNameSantos
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person.givenNamePatrícia A. B.
person.givenNameSara
person.givenNameEduardo
person.givenNameMariana
person.givenNameEzequiel
person.givenNameSónia
person.givenNameMaria Manuela
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person.identifier.ciencia-idF017-D326-8496
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0002-1922-6937
person.identifier.orcid0000-0001-8268-2137
person.identifier.orcid0000-0003-3121-4514
person.identifier.orcid0000-0002-1815-3270
person.identifier.orcid0000-0003-4496-2001
person.identifier.orcid0000-0002-6749-7619
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridU-1916-2017
person.identifier.ridJ-7033-2016
person.identifier.ridL-2173-2015
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55628816700
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person.identifier.scopus-author-id56986455000
person.identifier.scopus-author-id35783666600
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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