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Effect of mannan oligosaccharides extracts in uropathogenic escherichia coli adhesion in human bladder cells

2023Journal article Open access
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dc.contributor.authorFaustino, Margarida
dc.contributor.authorSilva, Sara
dc.contributor.authorCosta, Eduardo M.
dc.contributor.authorPereira, Ana Margarida
dc.contributor.authorPereira, Joana Odila
dc.contributor.authorOliveira, Ana Sofia
dc.contributor.authorFerreira, Carlos M. H.
dc.contributor.authorPereira, Carla F.
dc.contributor.authorDurão, Joana
dc.contributor.authorPintado, Manuela E.
dc.contributor.authorCarvalho, Ana P.
dc.date.accessioned2023-07-10T15:32:21Z
dc.date.available2023-07-10T15:32:21Z
dc.date.issued2023
dc.description.abstractUrinary tract infections (UTIs) are a common public health problem, mainly caused by uropathogenic Escherichia coli (UPEC). Patients with chronic UTIs are usually treated with long-acting prophylactic antibiotics, which promotes the development of antibiotic-resistant UPEC strains and may complicate their long-term management. D-mannose and extracts rich in D-mannose such as mannan oligosaccharides (MOS; D-mannose oligomers) are promising alternatives to antibiotic prophylaxis due to their ability to inhibit bacterial adhesion to urothelial cells and, therefore, infection. This highlights the therapeutic potential and commercial value of using them as health supplements. Studies on the effect of MOS in UTIs are, however, scarce. Aiming to evaluate the potential benefits of using MOS extracts in UTIs prophylaxis, their ability to inhibit the adhesion of UPEC to urothelial cells and its mechanism of action were assessed. Additionally, the expression levels of the pro-inflammatory marker interleukin 6 (IL-6) were also evaluated. After characterizing their cytotoxic profiles, the preliminary results indicated that MOS extracts have potential to be used for the handling of UTIs and demonstrated that the mechanism through which they inhibit bacterial adhesion is through the competitive inhibition of FimH adhesins through the action of mannose, validated by a bacterial growth impact assessment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/pathogens12070885pt_PT
dc.identifier.eid85167854555
dc.identifier.issn2076-0817
dc.identifier.pmcPMC10384913
dc.identifier.pmid37513732
dc.identifier.urihttp://hdl.handle.net/10400.14/41637
dc.identifier.wos001038849500001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectUropathogenic Escherichia coli (UPEC)pt_PT
dc.subjectMannan oligosaccharides (MOS)pt_PT
dc.subjectAdhesionpt_PT
dc.subjectBladder cellspt_PT
dc.subjectD-mannosept_PT
dc.subjectUrinary tract infections (UTIs)pt_PT
dc.titleEffect of mannan oligosaccharides extracts in uropathogenic escherichia coli adhesion in human bladder cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.titlePathogenspt_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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