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Sargassum muticum and Osmundea pinnatifida enzymatic extracts: chemical, structural, and cytotoxic characterization

2019Journal article Open access
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dc.contributor.authorRodrigues, Dina
dc.contributor.authorCosta-Pinto, Ana R.
dc.contributor.authorSousa, Sérgio
dc.contributor.authorVasconcelos, Marta W.
dc.contributor.authorPintado, Manuela M.
dc.contributor.authorPereira, Leonel
dc.contributor.authorRocha-Santos, Teresa A. P.
dc.contributor.authorCosta, João P. da
dc.contributor.authorSilva, Artur M. S.
dc.contributor.authorDuarte, Armando C.
dc.contributor.authorGomes, Ana M. P.
dc.contributor.authorFreitas, Ana C.
dc.date.accessioned2019-04-12T11:36:18Z
dc.date.available2019-04-12T11:36:18Z
dc.date.issued2019
dc.description.abstractSeaweeds, which have been widely used for human consumption, are considered a potential source of biological compounds, where enzyme-assisted extraction can be an efficient method to obtain multifunctional extracts. Chemical characterization of Sargassum muticum and Osmundea pinnatifida extracts obtained by Alcalase and Viscozyme assisted extraction, respectively, showed an increment of macro/micro elements in comparison to the corresponding dry seaweeds, while the ratio of Na/K decreased in both extracts. Galactose, mannose, xylose, fucose, and glucuronic acid were the main monosaccharides (3.2–27.3 mg/glyophilized extract) present in variable molar ratios, whereas low free amino acids content and diversity (1.4–2.7 g/100gprotein) characterized both extracts. FTIR-ATR and 1H NMR spectra confirmed the presence of important polysaccharide structures in the extracts, namely fucoidans from S. muticum or agarans as sulfated polysaccharides from O. pinnatifida. No cytotoxicity against normal mammalian cells was observed from 0 to 4 mglyophilized extract/mL for both extracts. The comprehensive characterization of the composition and safety of these two extracts fulfils an important step towards their authorized application for nutritional and/or nutraceutical purposes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRodrigues, D., Costa-Pinto, A. R., Sousa, S., Vasconcelos, M. W., Pintado, M. M., Pereira, L., … Freitas, A. C. (2019). Sargassum muticum and Osmundea pinnatifida Enzymatic Extracts: chemical, Structural, and Cytotoxic Characterization. Marine Drugs, 17(4), 209. https://doi.org/10.3390/md17040209pt_PT
dc.identifier.doi10.3390/md17040209pt_PT
dc.identifier.eid85064411061
dc.identifier.issn1660-3397
dc.identifier.pmcPMC6520698
dc.identifier.pmid30987249
dc.identifier.urihttp://hdl.handle.net/10400.14/27392
dc.identifier.wos000467307100016
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationNORTE-01-0145-FEDER-000012
dc.relationMARE - Marine and Environmental Sciences Centre
dc.relationMonitoring of marine environment contaminants in real-time by an autonomous biosensor platform
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectOsmundea pinnatifidapt_PT
dc.subjectSargassum muticumpt_PT
dc.subjectEnzymatic extractspt_PT
dc.subjectMineralspt_PT
dc.subjectMono and polysaccharidespt_PT
dc.subjectFTIR-ATRpt_PT
dc.subjectNMRpt_PT
dc.subjectCytotoxicitypt_PT
dc.titleSargassum muticum and Osmundea pinnatifida enzymatic extracts: chemical, structural, and cytotoxic characterizationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMARE - Marine and Environmental Sciences Centre
oaire.awardTitleMonitoring of marine environment contaminants in real-time by an autonomous biosensor platform
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMAR%2F04292%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00407%2F2013%2FCP1162%2FCT0023/PT
oaire.citation.titleMarine Drugspt_PT
oaire.fundingStream5876
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamInvestigador FCT
person.familyNameRodrigues
person.familyNameCosta-Pinto
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person.familyNamePereira
person.familyNameRocha-Santos
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person.familyNameSilva
person.familyNameDuarte
person.familyNameGomes
person.familyNameCardoso Freitas Lopes de Freitas
person.givenNameDina
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person.givenNameMarta
person.givenNameMaria Manuela
person.givenNameLeonel
person.givenNameTeresa
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person.givenNameArtur
person.givenNameArmando
person.givenNameAna Maria
person.givenNameAna Cristina
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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