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Ultrasound sonication prior to electrospinning tailors silk fibroin/PEO membranes for periodontal regeneration

2019Journal article Restricted access
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dc.contributor.authorSerôdio, Ricardo
dc.contributor.authorSchickert, Sónia L.
dc.contributor.authorCosta-Pinto, Ana R.
dc.contributor.authorDias, Juliana R.
dc.contributor.authorGranja, Pedro L.
dc.contributor.authorYang, Fang
dc.contributor.authorOliveira, Ana L.
dc.date.accessioned2019-01-31T17:21:05Z
dc.date.available2019-01-31T17:21:05Z
dc.date.issued2019
dc.description.abstractIn this study, silk fibroin (SF)/poly(ethylene oxide) (PEO) membranes were designed and fabricated by combining ultrasound sonication prior to electrospinning (0 to 20 min) as a strategy to physically control the rheological properties of solutions (10 to 30% w/v PEO) and to improve the spinnability of the system. PEO has proved to be essential as a co-spinning agent to assure good membrane reproducibility and enough flexibility for clinical manipulation. The rheological tests indicated that sonication greatly increased the viscosity of SF/PEO solutions and further enhanced the quality of the produced electrospun fibers with consequent improved mechanical properties in dry and wet conditions. By tuning the viscosity of the solutions using a simple sonication step prior to electrospinning, it was possible to induce water stability in the as-electrospun matrix, as demonstrated by infra-red spectroscopy. This reduced complexity in the process since it was not necessary to concentrate silk prior to electrospinning while avoiding the use of toxic solvents to perform a post-processing stabilization treatment which usually causes dimensional changes to the SF materials. Sonication pre-treatment allowed for minimizing the amount of synthetic polymer used to achieve the desirable mechanical properties (with the modulus ranging between 90 and 170 MPa), while avoiding a further water stabilization treatment. It also had a positive impact in the in vitro cell behavior of human primary periodontal ligament cells (hPDLs), resulting in a marked increase in cell proliferation. The present developed work constitutes a step forward towards simplicity and a better fabrication control of viable electrospun SF-based membranes for periodontal regeneration.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSerôdio, R., Schickert, S. L., Costa-Pinto, A. R., Dias, J. R., Granja, P. L., Yang, F., & Oliveira, A. L. (2019). Ultrasound sonication prior to electrospinning tailors silk fibroin/PEO membranes for periodontal regeneration. Materials Science and Engineering: C, 98, 969–981. https://doi.org/10.1016/j.msec.2019.01.055pt_PT
dc.identifier.doi10.1016/j.msec.2019.01.055pt_PT
dc.identifier.eid85060099646
dc.identifier.eissn1873-0191
dc.identifier.issn0928-4931
dc.identifier.pmid30813104
dc.identifier.urihttp://hdl.handle.net/10400.14/26788
dc.identifier.wos000461526800096
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIF/00411/2013
dc.relationIF/00411/2013/CP1167
dc.relation0245_IBEROS_1_E
dc.subjectSilk fibroinpt_PT
dc.subjectPoly(ethylene oxide) membranept_PT
dc.subjectPeriodontal regenerationpt_PT
dc.subjectElectrospinningpt_PT
dc.subjectUltrasound sonicationpt_PT
dc.titleUltrasound sonication prior to electrospinning tailors silk fibroin/PEO membranes for periodontal regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.citation.endPage981pt_PT
oaire.citation.startPage969pt_PT
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume98pt_PT
oaire.fundingStream5876
person.familyNameSerôdio
person.familyNameCosta-Pinto
person.familyNameDias
person.familyNameGranja
person.familyNameYang
person.givenNameRicardo
person.givenNameAna Rita
person.givenNameJuliana
person.givenNamePedro
person.givenNameFang
person.identifier633669
person.identifier1017757
person.identifier.ciencia-id1313-66B7-2A1E
person.identifier.ciencia-id0612-D971-F00D
person.identifier.ciencia-idDB1F-B9B7-E4FD
person.identifier.orcid0000-0003-2762-641X
person.identifier.orcid0000-0002-4764-8539
person.identifier.orcid0000-0002-7079-1069
person.identifier.orcid0000-0003-2761-4929
person.identifier.orcid0000-0002-4022-7643
person.identifier.ridI-7483-2013
person.identifier.ridV-9083-2017
person.identifier.ridB-1685-2008
person.identifier.ridE-1937-2011
person.identifier.scopus-author-id24390737500
person.identifier.scopus-author-id55493446000
person.identifier.scopus-author-id6602391346
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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