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Phenolic compounds' impact on gut microbiota: insights from in vitro batch fecal fermentation for composition modulation

2026-03-31Artigo de investigação Acesso aberto
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dc.contributor.authorPais, Adriana C. S.
dc.contributor.authorRibeiro, Tânia B.
dc.contributor.authorCoscueta, Ezequiel R.
dc.contributor.authorSalsinha, Ana Sofia
dc.contributor.authorPintado, Maria Manuela
dc.contributor.authorSilvestre, Armando J. D.
dc.contributor.authorSantos, Sónia A. O.
dc.date.accessioned2026-01-15T09:08:08Z
dc.date.available2026-01-15T09:08:08Z
dc.date.issued2026-03-31
dc.description.abstractThe relationship between phenolic compounds and gut microbiota (has been widely studied to explore the health benefits of these bioactive dietary compounds. Phenolic compounds are metabolized by gut microbiota, while also modulating its composition. However, the individual effects of these compounds on human gut microbiota remain underexplored. To address this, three phenolic compouds—ellagic acid, naringenin, and phloroglucinol—underwent in vitro batch fermentation with fecal samples from healthy donors. Samples were analyzed through 16S metagenomics sequencing, and short-chain fatty acids (SCFAs) were measured using gas chromatography.Results showed that ellagic acid and phloroglucinol had prebiotic properties, producing SCFAs like acetic, propanoic, and butyric acids and promoting the growth of beneficial bacteria such as Lactobacillus and Bifidobacterium. In contrast, naringenin was linked to the growth of pathogenic genera like Escherichia and Salmonella. This study provides valuable insights into how specific phenolic compounds influence gut microbiota composition, contributing to potential pharmaceutical or nutraceutical developments.eng
dc.identifier.citationPais, A. C. S., Ribeiro, T. B., Coscueta, E. R., & Salsinha, A. S. et al. (2026). Phenolic compounds' impact on gut microbiota: insights from in vitro batch fecal fermentation for composition modulation. Food research international, 228, Article 118167. https://doi.org/10.1016/j.foodres.2025.118167
dc.identifier.doi10.1016/j.foodres.2025.118167
dc.identifier.eid105026837972
dc.identifier.issn0963-9969
dc.identifier.otherc2ead4fe-5c3a-402c-b760-e30083dc534f
dc.identifier.urihttp://hdl.handle.net/10400.14/56520
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBatch fecal fermentation
dc.subjectComposition modulation
dc.subjectHuman gut microbiota
dc.subjectPhenolic compounds
dc.subjectSCFAs
dc.titlePhenolic compounds' impact on gut microbiota: insights from in vitro batch fecal fermentation for composition modulationeng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleFood research international
oaire.citation.volume228
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa

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