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Phytochemical analysis, antioxidant, antifungal activity, and genotoxicity of essential oil and solvent extracts of tetraclinis articulata leaves from northern Morocco

2024-03-30Journal article Open access
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dc.contributor.authorBenoutman, Amina
dc.contributor.authorErbiai, El Hadi
dc.contributor.authorEttakifi, Hajar
dc.contributor.authorLegssyer, Mounir
dc.contributor.authorHandaq, Nadia
dc.contributor.authorMakrane, Hanane
dc.contributor.authorSaidi, Rabah
dc.contributor.authorLamrani, Zouhaire
dc.contributor.authorPintado, Manuela
dc.contributor.authorPinto, Eugénia
dc.contributor.authorSilva, Joaquim C. G. Esteves da
dc.contributor.authorMaouni, Abdelfettah
dc.date.accessioned2024-10-17T16:50:45Z
dc.date.available2024-10-17T16:50:45Z
dc.date.issued2024-03-30
dc.description.abstractTetraclinis articulata is a medicinal plant commonly known in Morocco as” Araar Tree “. Various parts of T. articulata are traditionally used for various therapeutic purposes. In this context, the present study aims to evaluate the antioxidant, antifungal, and genotoxicity of methanolic (TaLME), acetonic (TaLAE) extracts, and essential oil (TaLEO) from Tetraclinis articulata leaves growing in northern Morocco. This was carried out through chemical analysis, bioactive substance determination, and essential oil and extract testing. The bioactive substances determined by the spectrophotometric method showed a higher content of phenols and flavonoids in TaLME. The Liquid chromatography-mass spectrometry (LC-MS) analysis of phenolic compounds revealed protocatechuic acid as predominant in TaLME, followed by paraben acid and syringic acid, and in TaLAE, p-hydroxybenzoic was the principal compound, followed by protocatechuic acid and vanillic acid. The gas chromatography-mass spectrometry (GC-MS) analysis of TaLEO (yield of 0.77 %) revealed the presence of 22 compounds (95.80 %) with main components (%) α-pinene (29.62), bornyl acetate (21.45), and camphor (16.80). Biological activities were evaluated: antioxidant efficiency using four different methods (DPPH, ABTS, FRAP, ORAC), deoxyribonucleic acid (DNA) protection, genotoxicity test, and antifungal activity against five pathogenic fungi (Aspergillus fumigatus, Candida albicans, Epidermophyton floccosum, Trichophyton rubrum, and Microsporum canis). According to the results, the extracts and EO had significant antioxidant and antifungal activity against the dermatophytes. The genotoxicity test exhibited that the T. articulata extracts and EO were bereft of any mutagenic activity. Overall, this study demonstrates that Tetraclinis articulata plant essential oil and extracts can represent an intriguing potential source of natural compounds that can be helpful for future investigations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.33263/LIANBS131.050pt_PT
dc.identifier.eid85205691942
dc.identifier.issn2284-6808
dc.identifier.urihttp://hdl.handle.net/10400.14/47022
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntifungal activitypt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectBiochemical compositionpt_PT
dc.subjectEssential oilpt_PT
dc.subjectFlavonoidspt_PT
dc.subjectGenotoxicity testpt_PT
dc.subjectPhenolspt_PT
dc.subjectTetraclinis articulatapt_PT
dc.titlePhytochemical analysis, antioxidant, antifungal activity, and genotoxicity of essential oil and solvent extracts of tetraclinis articulata leaves from northern Moroccopt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleLetters in Applied NanoBioSciencept_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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