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Blueberry consumption challenges hepatic mitochondrial bioenergetics and elicits transcriptomics reprogramming in healthy wistar rats

2020-11Journal article Open access
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dc.contributor.authorNunes, Sara
dc.contributor.authorViana, Sofia D.
dc.contributor.authorPreguiça, Inês
dc.contributor.authorAlves, André
dc.contributor.authorFernandes, Rosa
dc.contributor.authorTeodoro, João S.
dc.contributor.authorFigueirinha, Artur
dc.contributor.authorSalgueiro, Lígia
dc.contributor.authorSilva, Sara
dc.contributor.authorJarak, Ivana
dc.contributor.authorCarvalho, Rui A.
dc.contributor.authorCavadas, Cláudia
dc.contributor.authorRolo, Anabela P.
dc.contributor.authorPalmeira, Carlos M.
dc.contributor.authorPintado, Maria M.
dc.contributor.authorReis, Flávio
dc.date.accessioned2020-12-10T12:19:24Z
dc.date.available2020-12-10T12:19:24Z
dc.date.issued2020-11
dc.description.abstractAn emergent trend of blueberries’ (BB) “prophylactic” consumption, due to their phytochemicals’ richness and well-known health-promoting claims, is widely scaled-up. However, the benefits arising from BB indiscriminate intake remains puzzling based on incongruent preclinical and human data. To provide a more in-depth elucidation and support towards a healthier and safer consumption, we conducted a translation-minded experimental study in healthy Wistar rats that consumed BB in a juice form (25 g/kg body weight (BW)/day; 14 weeks’ protocol). Particular attention was paid to the physiological adaptations succeeding in the gut and liver tissues regarding the acknowledged BB-induced metabolic benefits. Systemically, BB boosted serum antioxidant activity and repressed the circulating levels of 3-hydroxybutyrate (3-HB) ketone bodies and 3-HB/acetoacetate ratio. Moreover, BB elicited increased fecal succinic acid levels without major changes on gut microbiota (GM) composition and gut ultra-structural organization. Remarkably, an accentuated hepatic mitochondrial bioenergetic challenge, ensuing metabolic transcriptomic reprogramming along with a concerted anti-inflammatory pre-conditioning, was clearly detected upon long-term consumption of BB phytochemicals. Altogether, the results disclosed herein portray a quiescent mitochondrial-related metabolomics and hint for a unified adaptive response to this nutritional challenge. The beneficial or noxious consequences arising from this dietary trend should be carefully interpreted and necessarily claims future research.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNunes, S., Viana, S.D., Preguiça, I., Alves, A., Fernandes, R., Teodoro, J.S., … Reis, F. (2020). Blueberry consumption challenges hepatic mitochondrial bioenergetics and elicits transcriptomics reprogramming in healthy wistar rats. Pharmaceutics, 12(11)pt_PT
dc.identifier.doi10.3390/pharmaceutics12111094pt_PT
dc.identifier.eid85096072381
dc.identifier.issn1999-4923
dc.identifier.pmcPMC7697217
dc.identifier.pmid33202669
dc.identifier.urihttp://hdl.handle.net/10400.14/31442
dc.identifier.wos000594509400001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCENTRO-01-0145-FEDER-000012-HealthyAging2020pt_PT
dc.relationCNC. IBILI
dc.relationCenter for Innovative Biomedicine and Biotechnology
dc.relationCenter for Innovative Biomedicine and Biotechnology
dc.relationCrosstalk between gut microbiota and metabolic dysregulation in prediabetes – Impact of nutraceutical and therapeutic approaches
dc.relationPOCI-01-0145-FEDER-007440pt_PT
dc.relationPOCI-01-0145-FEDER-031712pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationCEECIND/04400/2017pt_PT
dc.relationREEQ/481/QUI/2006pt_PT
dc.relationUC-NMR: a voyage from chemical space to biological function
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBlueberriespt_PT
dc.subjectLong-term consumptionpt_PT
dc.subjectBioenergetics remodelingpt_PT
dc.subjectTranscriptomics reprogrammingpt_PT
dc.subjectAnti-inflammatory pre-conditioningpt_PT
dc.titleBlueberry consumption challenges hepatic mitochondrial bioenergetics and elicits transcriptomics reprogramming in healthy wistar ratspt_PT
dc.typejournal article
dspace.entity.typePublication
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oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology
oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology
oaire.awardTitleCrosstalk between gut microbiota and metabolic dysregulation in prediabetes – Impact of nutraceutical and therapeutic approaches
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleUC-NMR: a voyage from chemical space to biological function
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oaire.citation.issue11pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume12pt_PT
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person.familyNameBordalo Machado Figueirinha
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person.givenNameSara Raquel
person.givenNameAndré
person.givenNameRosa Cristina S
person.givenNameJoão
person.givenNameArtur Manuel
person.givenNameSara
person.givenNameMaria Manuela
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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