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Recent insights in the use of nanocarriers for the oral delivery of bioactive proteins and peptides

2018Journal article Restricted access
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dc.contributor.authorBatista, Patrícia
dc.contributor.authorCastro, Pedro M.
dc.contributor.authorMadureira, Ana Raquel
dc.contributor.authorSarmento, Bruno
dc.contributor.authorPintado, Manuela
dc.date.accessioned2018-09-19T14:48:22Z
dc.date.available2018-09-19T14:48:22Z
dc.date.issued2018
dc.description.abstractBioactive proteins and peptides have been used with either prophylactic or therapeutic purposes, presenting inherent advantages as high specificity and biocompatibility. Nanocarriers play an important role in the stabilization of proteins and peptides, offering enhanced buccal permeation and protection while crossing the gastrointestinal tract. Moreover, preparation of nanoparticles as oral delivery systems for proteins/peptides may include tailored formulation along with functionalization aiming bioavailability enhancement of carried proteins or peptides. Oral delivery systems, namely buccal delivery systems, represent an interesting alternative route to parenteric delivery systems to carry proteins and peptides, resulting in higher comfort of administration and, therefore, compliance to treatment. This paper outlines an extensive overview of the existing publications on proteins/peptides oral nanocarriers delivery systems, with special focus on buccal route. Manufacturing aspects of most commonly used nanoparticles for oral delivery (e.g. polymeric nanoparticles using synthetic or natural polymers and lipid nanoparticles) advantages and limitations and potential applications of nanoparticles as proteins/peptides delivery systems will also be thoroughly addressed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBatista, P., Castro, P.M., Madureira, A.R., Sarmento, B., Pintado, M.E. (2018). Recent insights in the use of nanocarriers for the oral delivery of bioactive proteins and peptides. Peptides, 101, 112–123pt_PT
dc.identifier.doi10.1016/j.peptides.2018.01.002pt_PT
dc.identifier.eid85040736226
dc.identifier.eissn1873-5169
dc.identifier.issn0196-9781
dc.identifier.pmid29329977
dc.identifier.urihttp://hdl.handle.net/10400.14/25707
dc.identifier.wos000426446000014
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationNORTE-08-5369-FSE-000007pt_PT
dc.relationDevelopment of oral strips containing nanoencapsulated bioactive compounds
dc.relationPOCI-01-0145-FEDER-007274pt_PT
dc.subjectBioactive protein/peptidespt_PT
dc.subjectBuccal deliverypt_PT
dc.subjectDelivery systemspt_PT
dc.subjectNanoparticlespt_PT
dc.subjectOral deliverypt_PT
dc.titleRecent insights in the use of nanocarriers for the oral delivery of bioactive proteins and peptidespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of oral strips containing nanoencapsulated bioactive compounds
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBBB-NAN%2F3249%2F2014/PT
oaire.citation.endPage123
oaire.citation.startPage112
oaire.citation.titlePeptidespt_PT
oaire.citation.volume101
oaire.fundingStream3599-PPCDT
person.familyNameBatista
person.familyNameMiranda de Castro
person.familyNameMadureira
person.familyNameSarmento
person.familyNamePintado
person.givenNamePatrícia
person.givenNamePedro João
person.givenNameRaquel
person.givenNameBruno
person.givenNameMaria Manuela
person.identifierAAF-7021-2020
person.identifierM-4659-2013
person.identifier152609
person.identifier456608
person.identifier.ciencia-idCB17-644F-65AC
person.identifier.ciencia-id5112-6B99-DC1F
person.identifier.ciencia-id1C14-25F8-CC07
person.identifier.ciencia-idE816-B6B0-06A5
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-3007-7263
person.identifier.orcid0000-0001-7164-8005
person.identifier.orcid0000-0001-6596-1927
person.identifier.orcid0000-0001-5763-7553
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridM-4659-2013
person.identifier.ridJ-6265-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id37092408800
person.identifier.scopus-author-id57201808340
person.identifier.scopus-author-id8384097900
person.identifier.scopus-author-id57194334236
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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