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Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

2022-10-10Journal article Open access
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dc.contributor.authorBarbacena, Pedro
dc.contributor.authorDominguez-Cejudo, Maria
dc.contributor.authorFonseca, Catarina G.
dc.contributor.authorGómez-González, Manuel
dc.contributor.authorFaure, Laura M.
dc.contributor.authorZarkada, Georgia
dc.contributor.authorPena, Andreia
dc.contributor.authorPezzarossa, Anna
dc.contributor.authorRamalho, Daniela
dc.contributor.authorGiarratano, Ylenia
dc.contributor.authorOuarné, Marie
dc.contributor.authorBarata, David
dc.contributor.authorFortunato, Isabela C.
dc.contributor.authorMisikova, Lenka Henao
dc.contributor.authorMauldin, Ian
dc.contributor.authorCarvalho, Yulia
dc.contributor.authorTrepat, Xavier
dc.contributor.authorRoca-Cusachs, Pere
dc.contributor.authorEichmann, Anne
dc.contributor.authorBernabeu, Miguel O.
dc.contributor.authorFranco, Cláudio A.
dc.date.accessioned2022-10-19T08:23:38Z
dc.date.available2022-10-19T08:23:38Z
dc.date.issued2022-10-10
dc.description.abstractBlood-vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that the transition between two fundamental vascular morphogenetic programs—sprouting angiogenesis and vascular remodeling—is established by a shift of collective front-to-rear polarity of endothelial cells in the mouse retina. We demonstrate that the competition between biochemical (VEGFA) and mechanical (blood-flow-induced shear stress) cues controls this collective polarity shift. Shear stress increases tension at focal adhesions overriding VEGFA-driven collective polarization, which relies on tension at adherens junctions. We propose that vascular morphogenetic cues compete to regulate individual cell polarity and migration through tension shifts that translates into tissue-level emergent behaviors, ultimately leading to uniquely organized vascular patterns.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.devcel.2022.09.002pt_PT
dc.identifier.eid85139362088
dc.identifier.issn1534-5807
dc.identifier.pmcPMC9552591
dc.identifier.pmid36220082
dc.identifier.urihttp://hdl.handle.net/10400.14/39144
dc.identifier.wos000898428700008
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAngiogenesispt_PT
dc.subjectCell polaritypt_PT
dc.subjectMechanobiologypt_PT
dc.subjectMorphogenesispt_PT
dc.subjectShear stresspt_PT
dc.titleCompetition for endothelial cell polarity drives vascular morphogenesis in the mouse retinapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2333.e9pt_PT
oaire.citation.issue19pt_PT
oaire.citation.startPage2321pt_PT
oaire.citation.titleDevelopmental Cellpt_PT
oaire.citation.volume57pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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