Publicação
Understanding the anti-obesity potential of an avocado oil-rich cheese through an in vitro co-culture intestine cell model
| dc.contributor.author | Machado, Manuela | |
| dc.contributor.author | Costa, Eduardo M. | |
| dc.contributor.author | Silva, Sara | |
| dc.contributor.author | Rodriguez-Alcalá, Luís M. | |
| dc.contributor.author | Gomes, Ana Maria | |
| dc.contributor.author | Pintado, Manuela | |
| dc.date.accessioned | 2023-09-15T14:35:18Z | |
| dc.date.available | 2023-09-15T14:35:18Z | |
| dc.date.issued | 2023-08-07 | |
| dc.description.abstract | Nowadays, with consumers’ requirements shifting towards more natural solutions and the advent of nutraceutical-based approaches, new alternatives for obesity management are being developed. This work aimed to show, for the first time, the potential of avocado oil-fortified cheese as a viable foodstuff for obesity management through complex in vitro cellular models. The results showed that oleic and palmitic acids’ permeability through the Caco-2/HT29-MTX membrane peaked at the 2h mark, with the highest apparent permeability being registered for oleic acid (0.14 cm/s). Additionally, the permeated compounds were capable of modulating the metabolism of adipocytes present in the basal compartment, significantly reducing adipokine (leptin) and cytokine (MPC-1, IL-10, and TNF-α) production. The permeates (containing 3.30 µg/mL of palmitic acid and 2.16 µg/mL of oleic acid) also presented an overall anti-inflammatory activity upon Raw 264.7 macrophages, reducing IL-6 and TNF-α secretion. Despite in vivo assays being required, the data showed the potential of a functional dairy product as a valid food matrix to aid in obesity management. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.3390/molecules28155923 | pt_PT |
| dc.identifier.eid | 85167767472 | |
| dc.identifier.issn | 1420-3049 | |
| dc.identifier.pmc | PMC10421176 | |
| dc.identifier.pmid | 37570893 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/42391 | |
| dc.identifier.wos | 001046310500001 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Anti-inflammatory potential | pt_PT |
| dc.subject | Cell-based assays | pt_PT |
| dc.subject | Lipid digestion | pt_PT |
| dc.subject | Permeability | pt_PT |
| dc.title | Understanding the anti-obesity potential of an avocado oil-rich cheese through an in vitro co-culture intestine cell model | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 15 | pt_PT |
| oaire.citation.title | Molecules | pt_PT |
| oaire.citation.volume | 28 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |