Publication
Characterization and evaluation of commercial carboxymethyl cellulose potential as an active ingredient for cosmetics
| dc.contributor.author | Costa, Eduardo M. | |
| dc.contributor.author | Pereira, Carla F. | |
| dc.contributor.author | Ribeiro, Alessandra A. | |
| dc.contributor.author | Casanova, Francisca | |
| dc.contributor.author | Freixo, Ricardo | |
| dc.contributor.author | Pintado, Manuela | |
| dc.contributor.author | Ramos, Óscar L. | |
| dc.date.accessioned | 2022-07-11T15:35:59Z | |
| dc.date.available | 2022-07-11T15:35:59Z | |
| dc.date.issued | 2022-06-28 | |
| dc.description.abstract | Carboxymethyl cellulose is the most used water-soluble cellulose with applications in industries such as food, cosmetics, and tissue engineering. However, due to a perceived lack of biological activity, carboxymethyl cellulose is mostly used as a structural element. As such, this work sought to investigate whether CMC possesses relevant biological properties that could grant it added value as a cosmeceutical ingredient in future skincare formulations. To that end, CMC samples (Mw between 471 and 322 kDa) skin cell cytotoxicity, impact upon pro-collagen I α I production, and inflammatory response were evaluated. Results showed that samples were not cytotoxic towards HaCat and HDFa up to 10 mg/mL while simultaneously promoting intracellular production of pro-collagen I α I up by 228% relative to the basal metabolism, which appeared to be related to the highest DS and Mw. Additionally, CMC samples modulated HaCat immune response as they decreased by ca. 1.4-fold IL-8 production and increased IL-6 levels by ca. five fold. Despite this increase, only two samples presented IL-6 levels similar to those of the inflammation control. Considering these results, CMC showed potential to be a more natural alternative to traditional bioactive cosmetic ingredients and, as it is capable of being a bioactive and structural ingredient, it may play a key role in future skincare formulations. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.3390/app12136560 | pt_PT |
| dc.identifier.eid | 85133537033 | |
| dc.identifier.issn | 2076-3417 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/38159 | |
| dc.identifier.wos | 000825675700001 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Carboxymethyl cellulose | pt_PT |
| dc.subject | Cosmeceutical | pt_PT |
| dc.subject | Skin keratinocytes | pt_PT |
| dc.subject | Skin normal fibroblasts | pt_PT |
| dc.subject | Immunomodulation | pt_PT |
| dc.subject | Pro-collagen production | pt_PT |
| dc.title | Characterization and evaluation of commercial carboxymethyl cellulose potential as an active ingredient for cosmetics | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 16 | pt_PT |
| oaire.citation.issue | 13 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | Applied Sciences (Switzerland) | pt_PT |
| oaire.citation.volume | 12 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |