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Application of optimal experimental design concept to improve the estimation of model parameters in microbial thermal inactivation kinetics

2014Journal article Restricted access
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dc.contributor.authorGil, Maria M.
dc.contributor.authorMiller, Fátima A.
dc.contributor.authorSilva, Cristina L.M.
dc.contributor.authorBrandão, Teresa R. S.
dc.date.accessioned2015-05-12T15:21:18Z
dc.date.available2015-05-12T15:21:18Z
dc.date.issued2014
dc.description.abstractThe estimation of model parameters with high precision is of major importance in mathematical predictions. If a mathematical model is properly chosen and if the primary objective is to improve parameter estimation, underlying statistical theories can be applied. Precision increases with the number of experimental points. However, and in many situations,maximum precision is attained when sampling consists of replicates of specific experimental points. Experimental conditions can be optimized using the Doptimal design concept based on minimization of the generalized variance of the parameter estimates. The objective of this work was to use this methodology for the design of experiments for microbial inactivation processes described by a Gompertz-based model under isothermal and non-isothermal conditions. The application of D-optimal design concept considerably improved parameters precision, when compared to the commonly used heuristic designs.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationGIL, Maria M. ...[et al.] - Application of optimal experimental design concept to improve the estimation of model parameters in microbial thermal inactivation kinetics. Journal of Food Engineering. ISSN 0260-8774. Vol. 134 (2014), p. 59–66por
dc.identifier.doi10.1016/j.jfoodeng.2014.02.018
dc.identifier.eid84897466166
dc.identifier.issn0260-8774
dc.identifier.urihttp://hdl.handle.net/10400.14/17575
dc.identifier.wos000337658200008
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier
dc.relationGASEOUS OZONE AS A POTENTIAL ALTERNATIVE DISINFECTION METHOD FOR MODIFIED ATMOSPHERE PACKAGING FRESH-CUT PRODUCE WITH HIGH QUALITY AND SAFETY STANDARDS
dc.relationETHYLENE OXIDE AS A STERILISING AGENT OF MEDICAL DEVICES: LETHALITY ESTIMATION BY DEVELOPMENT OF KINETIC MODELLING STUDIES
dc.relationStrategic Project - LA 16 - 2011-2012
dc.subjectD-optimal experimental designpor
dc.subjectMicrobial thermal inactivationpor
dc.subjectMaximum inactivation ratepor
dc.subjectShoulder parameterpor
dc.subjectIsothermal and non-isothermal conditionspor
dc.titleApplication of optimal experimental design concept to improve the estimation of model parameters in microbial thermal inactivation kineticspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleGASEOUS OZONE AS A POTENTIAL ALTERNATIVE DISINFECTION METHOD FOR MODIFIED ATMOSPHERE PACKAGING FRESH-CUT PRODUCE WITH HIGH QUALITY AND SAFETY STANDARDS
oaire.awardTitleETHYLENE OXIDE AS A STERILISING AGENT OF MEDICAL DEVICES: LETHALITY ESTIMATION BY DEVELOPMENT OF KINETIC MODELLING STUDIES
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F65041%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F41419%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.citation.endPage66
oaire.citation.startPage59
oaire.citation.titleJournal of Food Engineering
oaire.citation.volume134
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGil
person.familyNameMiller
person.familyNameSilva
person.familyNameBrandão
person.givenNameMaria M
person.givenNameFatima
person.givenNameCristina
person.givenNameTeresa
person.identifierG-5364-2013
person.identifier1473674
person.identifierJ-9418-2012
person.identifier.ciencia-id7313-A289-DF48
person.identifier.ciencia-id3A17-0386-6C1B
person.identifier.ciencia-id6611-634A-132C
person.identifier.ciencia-id7B19-E23B-BB31
person.identifier.orcid0000-0002-8008-9839
person.identifier.orcid0000-0002-3715-6231
person.identifier.orcid0000-0002-0495-3955
person.identifier.orcid0000-0002-8857-6471
person.identifier.ridG-5364-2013
person.identifier.ridA-3568-2013
person.identifier.ridJ-9418-2012
person.identifier.scopus-author-id12785024700
person.identifier.scopus-author-id15056315100
person.identifier.scopus-author-id7201387397
person.identifier.scopus-author-id6602174128
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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