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Antihypertensive effect of spent brewer yeast peptide

2019Journal article Restricted access
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dc.contributor.authorAmorim, M.
dc.contributor.authorMarques, C.
dc.contributor.authorPereira, J. O.
dc.contributor.authorGuardão, L.
dc.contributor.authorMartins, M. J.
dc.contributor.authorOsório, H.
dc.contributor.authorMoura, D.
dc.contributor.authorCalhau, C.
dc.contributor.authorPinheiro, H.
dc.contributor.authorPintado, M.
dc.date.accessioned2019-07-22T09:00:35Z
dc.date.available2019-07-22T09:00:35Z
dc.date.issued2019
dc.description.abstractNumerous studies have investigated dietary approaches to prevent chronic lifestyle-related diseases, including hypertension. Spent brewer's yeast is the second largest byproduct originated by the brewing industry and it deserves considerable attention because of its high nutritional value, ca. 40% of its dry mass is rich in protein which can be hydrolyzed into biologically active peptides. To upgrade this byproduct, the aim of this study was initially in vitro assessment of biological properties, e.g. ACE inhibition and antioxidant activity, and then, the in vivo effect in short-term oral antihypertensive effect of hydrolyzed yeast fractions on a well characterized model to study hypertension - Spontaneously Hypertensive Rats (SHR). Here, it was demonstrated that the fraction with molecular weight below 3 kDa containing tri and tetra- peptides with hydrophobic amino acid residues - SPQW, PWW and RYW, causes the most noticeable decrease in systolic, diastolic and mean blood pressure of SHR and shows highest antioxidant effect. These properties highlight the potential use of yeast extract as nutraceutical or functional food ingredient for the management and treatment of hypertension with antioxidant effect.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAmorim, M., Marques, C., Pereira, J. O., Guardão, L., Martins, M. J., Osório, H., … Pintado, M. (2019). Antihypertensive effect of spent brewer yeast peptide. Process Biochemistry, 76, 213–218. https://doi.org/10.1016/j.procbio.2018.10.004pt_PT
dc.identifier.doi10.1016/j.procbio.2018.10.004pt_PT
dc.identifier.eid85055738053
dc.identifier.eissn1873-3298
dc.identifier.issn1359-5113
dc.identifier.urihttp://hdl.handle.net/10400.14/28001
dc.identifier.wos000457660100025
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAntihypertensive peptidespt_PT
dc.subjectAntioxidant peptidespt_PT
dc.subjectAngiotensin-converting enzymept_PT
dc.subjectSpent brewer yeastpt_PT
dc.subjectHypertensionpt_PT
dc.subjectFood peptidespt_PT
dc.titleAntihypertensive effect of spent brewer yeast peptidept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F81901%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.citation.endPage218
oaire.citation.startPage213
oaire.citation.titleProcess Biochemistrypt_PT
oaire.citation.volume76
oaire.fundingStreamSFRH
oaire.fundingStream5876
person.familyNameAmorim
person.familyNameOdila Pereira
person.familyNameMartins
person.familyNameOsorio
person.familyNameMoura
person.familyNameCalhau
person.familyNamePinheiro
person.familyNamePintado
person.givenNameMaria Manuela
person.givenNameJoana
person.givenNameMaria João
person.givenNameHugo
person.givenNameDaniel
person.givenNameConceição
person.givenNameHelder
person.givenNameMaria Manuela
person.identifier2343777
person.identifierR-000-BVW
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person.identifier.orcid0000-0002-1485-0423
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person.identifier.orcid0000-0003-3848-3362
person.identifier.orcid0000-0001-9567-3379
person.identifier.orcid0000-0001-6076-2670
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridL-4327-2014
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person.identifier.scopus-author-id55293251500
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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