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Mechanisms leading to gut dysbiosis in COVID-19: current evidence and uncertainties based on adverse outcome pathways

2022-09-14Journal article Open access
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dc.contributor.authorClerbaux, Laure Alix
dc.contributor.authorFillipovska, Julija
dc.contributor.authorMuñoz, Amalia
dc.contributor.authorPetrillo, Mauro
dc.contributor.authorCoecke, Sandra
dc.contributor.authorAmorim, Maria João
dc.contributor.authorGrenga, Lucia
dc.date.accessioned2022-10-12T08:42:31Z
dc.date.available2022-10-12T08:42:31Z
dc.date.issued2022-09-14
dc.description.abstractAlteration in gut microbiota has been associated with COVID-19. However, the underlying mechanisms remain poorly understood. Here, we outlined three potential interconnected mechanistic pathways leading to gut dysbiosis as an adverse outcome following SARS-CoV-2 presence in the gastrointestinal tract. Evidence from the literature and current uncertainties are reported for each step of the different pathways. One pathway investigates evidence that intestinal infection by SARS-CoV-2 inducing intestinal inflammation alters the gut microbiota. Another pathway links the binding of viral S protein to angiotensin-converting enzyme 2 (ACE2) to the dysregulation of this receptor, essential in intestinal homeostasis—notably for amino acid metabolism—leading to gut dysbiosis. Additionally, SARS-CoV-2 could induce gut dysbiosis by infecting intestinal bacteria. Assessing current evidence within the Adverse Outcome Pathway framework justifies confidence in the proposed mechanisms to support disease management and permits the identification of inconsistencies and knowledge gaps to orient further research.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/jcm11185400pt_PT
dc.identifier.eid85138740804
dc.identifier.issn2077-0383
dc.identifier.pmcPMC9505288
dc.identifier.pmid36143044
dc.identifier.urihttp://hdl.handle.net/10400.14/39117
dc.identifier.wos000858223400001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSARS-CoV-2 infectionpt_PT
dc.subjectCOVID-19pt_PT
dc.subjectGut dysbiosispt_PT
dc.subjectMicrobiotapt_PT
dc.subjectGastrointestinal disorderspt_PT
dc.subjectIntestinal inflammationpt_PT
dc.subjectACE2 dysregulationpt_PT
dc.titleMechanisms leading to gut dysbiosis in COVID-19: current evidence and uncertainties based on adverse outcome pathwayspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue18pt_PT
oaire.citation.titleJournal of Clinical Medicinept_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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