Publication
Circular economyeast: saccharomyces cerevisiae as a sustainable source of glucans and its safety for skincare application
| dc.contributor.author | Sousa, Pedro | |
| dc.contributor.author | Tavares-Valente, Diana | |
| dc.contributor.author | Pereira, Carla F. | |
| dc.contributor.author | Pinto-Ribeiro, Inês | |
| dc.contributor.author | Azevedo-Silva, João | |
| dc.contributor.author | Madureira, Raquel | |
| dc.contributor.author | Ramos, Óscar L. | |
| dc.contributor.author | Pintado, Manuela | |
| dc.contributor.author | Fernandes, João | |
| dc.contributor.author | Amorim, Manuela | |
| dc.date.accessioned | 2024-04-03T15:28:44Z | |
| dc.date.available | 2024-04-03T15:28:44Z | |
| dc.date.issued | 2024-04 | |
| dc.description.abstract | Glucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have gained increasing attention for their potential as a skin ingredient. Therefore, this study focused on the extraction method to isolate and purify water-insoluble glucans from two different Saccharomyces cerevisiae strains: an engineered strain obtained from spent yeast in an industrial fermentation process and a wild strain produced through lab-scale fermentation. Two water-insoluble extracts with a high glucose content (> 90 %) were achieved and further subjected to a chemical modification using carboxymethylation to improve their water solubility. All the glucans' extracts, water-insoluble and carboxymethylated, were structurally and chemically characterized, showing almost no differences between both yeast-type strains. To ensure their safety for skin application, a broad safety assessment was undertaken, and no cytotoxic effect, immunomodulatory capacity (IL-6 and IL-8 regulation), genotoxicity, skin sensitization, and impact on the skin microbiota were observed. These findings highlight the potential of glucans derived from spent yeast as a sustainable and safe ingredient for cosmetic and skincare formulations, contributing to the sustainability and circular economy. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.ijbiomac.2024.130933 | pt_PT |
| dc.identifier.eid | 85189179079 | |
| dc.identifier.issn | 0141-8130 | |
| dc.identifier.pmid | 38508554 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/44440 | |
| dc.identifier.wos | 001223182500001 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Spent yeast | pt_PT |
| dc.subject | Glucans extraction | pt_PT |
| dc.subject | Skin safety | pt_PT |
| dc.title | Circular economyeast: saccharomyces cerevisiae as a sustainable source of glucans and its safety for skincare application | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | part 2 | pt_PT |
| oaire.citation.title | International Journal of Biological Macromolecules | pt_PT |
| oaire.citation.volume | 265 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |