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Allogenic synovia-derived mesenchymal stem cells for treatment of equine tendinopathies and desmopathies — proof of concept

2023-04-11Journal article Open access
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dc.contributor.authorReis, Inês Leal
dc.contributor.authorLopes, Bruna
dc.contributor.authorSousa, Patrícia
dc.contributor.authorSousa, Ana Catarina
dc.contributor.authorBranquinho, Mariana
dc.contributor.authorCaseiro, Ana Rita
dc.contributor.authorPedrosa, Sílvia Santos
dc.contributor.authorRêma, Alexandra
dc.contributor.authorOliveira, Cláudia
dc.contributor.authorPorto, Beatriz
dc.contributor.authorAtayde, Luís
dc.contributor.authorAmorim, Irina
dc.contributor.authorAlvites, Rui
dc.contributor.authorSantos, Jorge Miguel
dc.contributor.authorMaurício, Ana Colette
dc.date.accessioned2023-05-10T17:29:43Z
dc.date.available2023-05-10T17:29:43Z
dc.date.issued2023-04-11
dc.description.abstractTendon and ligament injuries are frequent in sport horses and humans, and such injuries represent a significant therapeutic challenge. Tissue regeneration and function recovery are the paramount goals of tendon and ligament lesion management. Nowadays, several regenerative treatments are being developed, based on the use of stem cell and stem cell-based therapies. In the present study, the preparation of equine synovial membrane mesenchymal stem cells (eSM-MSCs) is described for clinical use, collection, transport, isolation, differentiation, characterization, and application. These cells are fibroblast-like and grow in clusters. They retain osteogenic, chondrogenic, and adipogenic differentiation potential. We present 16 clinical cases of tendonitis and desmitis, treated with allogenic eSM-MSCs and autologous serum, and we also include their evaluation, treatment, and follow-up. The concerns associated with the use of autologous serum as a vehicle are related to a reduced immunogenic response after the administration of this therapeutic combination, as well as the pro-regenerative effects from the growth factors and immunoglobulins that are part of its constitution. Most of the cases (14/16) healed in 30 days and presented good outcomes. Treatment of tendon and ligament lesions with a mixture of eSM-MSCs and autologous serum appears to be a promising clinical option for this category of lesions in equine patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ani13081312pt_PT
dc.identifier.eid85153791162
dc.identifier.issn2076-2615
dc.identifier.pmcPMC10135243
dc.identifier.pmid37106875
dc.identifier.urihttp://hdl.handle.net/10400.14/41090
dc.identifier.wos000978207800001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAllogenicpt_PT
dc.subjectCell-based therapiespt_PT
dc.subjectClinical trialspt_PT
dc.subjectLigamentpt_PT
dc.subjectMesenchymal stem cellspt_PT
dc.subjectSport horsespt_PT
dc.subjectSynovial mesenchymal stem cellpt_PT
dc.subjectTendonpt_PT
dc.titleAllogenic synovia-derived mesenchymal stem cells for treatment of equine tendinopathies and desmopathies — proof of conceptpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.titleAnimalspt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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