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Neoadjuvant gastric cancer treatment and associated nutritional critical domains for the optimization of care pathways: a systematic review

2023Journal article Open access
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dc.contributor.authorCorreia, Marta
dc.contributor.authorMoreira, Ines
dc.contributor.authorCabral, Sonia
dc.contributor.authorCastro, Carolina
dc.contributor.authorCruz, Andreia
dc.contributor.authorMagalhães, Bruno
dc.contributor.authorSantos, Lúcio Lara
dc.contributor.authorIrving, Susana Couto
dc.date.accessioned2023-07-18T14:53:02Z
dc.date.available2023-07-18T14:53:02Z
dc.date.issued2023
dc.description.abstract(1) Background: Gastric cancer patients are known to be at a high risk of malnutrition, sarcopenia, and cachexia, and the latter impairs the patient’s nutritional status during their clinical course and also treatment response. A clearer identification of nutrition-related critical points during neoadjuvant treatment for gastric cancer is relevant to managing patient care and predicting clinical outcomes. The aim of this systematic review was to identify and describe nutrition-related critical domains associated with clinical outcomes. (2) Methods: We performed a systematic review (PROSPERO ID:CRD42021266760); (3) Results: This review included 14 studies compiled into three critical domains: patient-related, clinical-related (disease and treatment), and healthcare-related. Body composition changes during neoadjuvant chemotherapy (NAC) accounted for the early termination of chemotherapy and reduced overall survival. Sarcopenia was confirmed to have an independent prognostic value. The role of nutritional interventions during NAC has not been fully explored. (4) Conclusions: Understanding critical domain exposures affecting nutritional status will enable better clinical approaches to optimize care plans. It may also provide an opportunity for the mitigation of poor nutritional status and sarcopenia and their deleterious clinical consequences.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/nu15102241pt_PT
dc.identifier.eid85160296451
dc.identifier.issn2072-6643
dc.identifier.pmcPMC10223831
dc.identifier.pmid37242125
dc.identifier.urihttp://hdl.handle.net/10400.14/41760
dc.identifier.wos000995713400001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNeoadjuvant chemotherapypt_PT
dc.subjectNutrition impact symptomspt_PT
dc.subjectNutrition supportpt_PT
dc.subjectNutritional statuspt_PT
dc.subjectPre-operativept_PT
dc.subjectSarcopeniapt_PT
dc.subjectStomach neoplasmspt_PT
dc.titleNeoadjuvant gastric cancer treatment and associated nutritional critical domains for the optimization of care pathways: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue10pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume15pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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