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Bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospecting

2022-02Journal article Open access
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dc.contributor.authorAmorim, Adriany das Graças Nascimento
dc.contributor.authorVasconcelos, Andreanne Gomes
dc.contributor.authorSouza, Jessica
dc.contributor.authorOliveira, Ana
dc.contributor.authorGullón, Beatriz
dc.contributor.authorLeite, José Roberto de Souza de Almeida
dc.contributor.authorPintado, Manuela
dc.date.accessioned2022-03-03T10:48:29Z
dc.date.available2022-03-03T10:48:29Z
dc.date.issued2022-02
dc.description.abstractThe purpose of this review was to collect relevant chemical data about lycopene and its isomers, which can be extracted using different non-polar or polar aprotic solvents by SC-CO2 or biosynthesis as a friendly technique. Lycopene and other carotenoids can be identified and quantified by UV–Vis and HPLC using a C18 or C30 column, while their characterization is possible by UV–Vis, Fluorescence, FTIR, MS, NMR, and DSC assays. Among these techniques, the last four can compare lycopene isomers and identify cis or all-trans-lycopene. FTIR, MS, and NMR techniques are more suitable for the verification of the purity of lycopene extracts due to the signal complexity generated for each isomer, which enables identification by subtle differences. Additionally, some biological activities of lycopene isolated from red vegetables have already been confirmed, such as anti-inflammatory, antioxidant, and cytotoxic activity against cancer cells, probably by activating several pathways. The encapsulation of lycopene in nanoparticles demonstrated an improvement in oral delivery, and ex vivo assessments determined that these nanoparticles had better permeation and low cytotoxicity against human cells with enhanced permeation. These data suggest that lycopene has the potential to be applied in the food and pharmaceutical industries, as well as in cosmetic products.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/antiox11020360pt_PT
dc.identifier.eid85124289342
dc.identifier.issn2076-3921
dc.identifier.pmcPMC8868408
dc.identifier.pmid35204241
dc.identifier.urihttp://hdl.handle.net/10400.14/36863
dc.identifier.wos000770906900001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectBio-availabilitypt_PT
dc.subjectCancerpt_PT
dc.subjectLycopenept_PT
dc.subjectNanostructurept_PT
dc.titleBio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospectingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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