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Development of probiotic tablets using microparticles: viability studies and stability studies

2013Journal article Restricted access
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dc.contributor.authorSousa e Silva, J. P.
dc.contributor.authorSousa, Sérgio C.
dc.contributor.authorCosta, Paulo
dc.contributor.authorCerdeira, Emília
dc.contributor.authorAmaral, Maria H.
dc.contributor.authorLobo, José Sousa
dc.contributor.authorGomes, Ana M. P.
dc.contributor.authorPintado, Maria M.
dc.contributor.authorRodrigues, Dina
dc.contributor.authorRocha-Santos, Teresa
dc.contributor.authorFreitas, A. C.
dc.date.accessioned2013-01-28T12:37:36Z
dc.date.available2013-01-28T12:37:36Z
dc.date.issued2013
dc.description.abstractAlternative vectors to deliver viable cells of probiotics, to those conferring limited resistance to gastrointestinal conditions, still need to be sought. Therefore the main goal of the study was to develop tablets able to protect entrapped probiotic bacteria from gastric acidity, thus providing an easily manufacturing scale-up dosage form to deliver probiotics to the vicinity of the human colon. Whey protein concentrate microparticles with Lactobacillus paracasei L26 were produced by spray-drying and incorporated in tablets with cellulose acetate phthalate and sodium croscarmellose. The viability of L. paracasei L. 26 throughout tableting as well as its gastric resistance and release from the tablets were evaluated. Storage stability of L. paracasei L26 tablets was also performed by evaluation of viable cells throughout 60 days at 23 degrees C and 33% relative humidity. A decrease of approximately one logarithmic cycle was observed after the acid stage and the release of L. paracasei L26 from the tablets occurred only after 4 h in the conditions tested. Microencapsulated L. paracasei L26 in tablets revealed some susceptibility to the storage conditions tested since the number of viable cells decreased 2 log cycles after 60 days of storage. However, the viability of L. paracasei L26 after 45 days of storage did not reveal significant susceptibility upon exposure to simulated gastrointestinal conditions. The developed probiotic tablets revealed to be potential vectors for delivering viable cells of L. paracasei L26 and probably other probiotics to persons/patients who might benefit from probiotic therapy.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationSOUSA E SILVA, J. P....[et al.] - Development of Probiotic Tablets Using Microparticles: Viability Studies and Stability Studies. AAPS PharmSciTech. ISSN 1530-9932. (2013) vol.14, nº1, p.121-127por
dc.identifier.doi10.1208/s12249-012-9898-9
dc.identifier.issn1530-9932
dc.identifier.urihttp://hdl.handle.net/10400.14/9981
dc.identifier.wosWOS:000319798100015
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAmerican Association of Pharmaceutical Scientistspor
dc.relationFCOMP-01-0124-FEDER-008792
dc.relationPROBIOCAPS - tailored microencaPsulation technology foR prOBIOtic baCteriA: Production, stability and functionality enhancementS in various carriers
dc.relationNEWFUNFOODS: NEW FUNCTIONAL FOODS WITH INGREDIENTS FROM MARINE AND MUSHROOMS SOURCES
dc.relationDEVELOPMENT OF MONITORING STRATEGIES FOR NANOAEROSOLS
dc.subjectColonic drug deliverypor
dc.subjectLactobacillus paracaseipor
dc.subjectMicroencapsulationpor
dc.subjectRelease studiespor
dc.subjectTabletingpor
dc.titleDevelopment of probiotic tablets using microparticles: viability studies and stability studiespor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePROBIOCAPS - tailored microencaPsulation technology foR prOBIOtic baCteriA: Production, stability and functionality enhancementS in various carriers
oaire.awardTitleNEWFUNFOODS: NEW FUNCTIONAL FOODS WITH INGREDIENTS FROM MARINE AND MUSHROOMS SOURCES
oaire.awardTitleDEVELOPMENT OF MONITORING STRATEGIES FOR NANOAEROSOLS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F71051%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F73781%2F2010/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F65410%2F2009/PT
oaire.citation.endPage127
oaire.citation.issue1por
oaire.citation.startPage121
oaire.citation.titleAAPS PharmSciTech
oaire.citation.volume14
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamSFRH
person.familyNameSousa
person.familyNameCardoso da Costa
person.familyNameAmaral
person.familyNameGomes
person.familyNamePintado
person.familyNameRodrigues
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person.familyNameCardoso Freitas Lopes de Freitas
person.givenNameSérgio
person.givenNamePaulo Jorge
person.givenNameMaria Helena
person.givenNameAna Maria
person.givenNameMaria Manuela
person.givenNameDina
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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