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Monoterpene hydroxy lactones isolated from Thalassiosira sp. microalga and their antibacterial and antioxidant activities

2024-11Journal article Open access
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dc.contributor.authorMorais, Alcina M. M. B.
dc.contributor.authorKumla, Decha
dc.contributor.authorMartins, Valter F. R.
dc.contributor.authorAlves, Ana
dc.contributor.authorGales, Luis
dc.contributor.authorSilva, Artur M. S.
dc.contributor.authorCosta, Paulo M.
dc.contributor.authorMistry, Sharad
dc.contributor.authorKijjoa, Anake
dc.contributor.authorMorais, Rui M. S. C.
dc.date.accessioned2024-11-25T10:46:33Z
dc.date.available2024-11-25T10:46:33Z
dc.date.issued2024-11
dc.description.abstractTwo monoterpenoid lactones, loliolide (1) and epi-loliolide (2), were isolated from the crude dichloromethane extract of a microalga, Thalassiosira sp.). The structures of loliolide (1) and epi-loliolide (2) were elucidated by 1D and 2D NMR analysis, as well as a comparison of their 1H or/and 13C NMR data with those reported in the literature. In the case of loliolide (1), the absolute configurations of its stereogenic carbons were confirmed by X-ray analysis, whereas those of epi-loliolide (2) were determined by NOESY correlations. Loliolide (1) and epi-loliolide (2) were tested for their growth inhibitory activity against two Gram-positive (Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212) and two Gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853) bacteria, as well as one clinical isolate (E. coli SA/2, an extended-spectrum β-lactamase producer-ESBL) and two environmental isolates, S. aureus 74/24, a methicillin-resistant (MRSA), and E. faecalis B3/101, a vancomycin-resistant (VRE) isolates. The results showed that none of the tested compounds exhibited antibacterial activity at the highest concentrations tested (325 μM), and both revealed low antioxidant activity, with ORAC values of 2.786 ± 0.070 and 2.520 ± 0.319 µmol TE/100 mg for loliolide (1) and epi-loliolide (2), respectively.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/molecules29215175pt_PT
dc.identifier.eid85208580133
dc.identifier.issn1420-3049
dc.identifier.pmid39519816
dc.identifier.urihttp://hdl.handle.net/10400.14/47261
dc.identifier.wos001351824600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntibacterial activitypt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectEpi-loliolidept_PT
dc.subjectLoliolidept_PT
dc.subjectMicroalgaept_PT
dc.subjectMonoterpenoid lactonespt_PT
dc.subjectThalassiosira sppt_PT
dc.titleMonoterpene hydroxy lactones isolated from Thalassiosira sp. microalga and their antibacterial and antioxidant activitiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue21pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume29pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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