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Bioinformatic insights into the carotenoids’ role in gut microbiota dynamics

2026-01-20Artigo de investigação Acesso aberto
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dc.contributor.authorRocha, Helena R.
dc.contributor.authorRibeiro, Pedro
dc.contributor.authorRodrigues, Pedro Miguel
dc.contributor.authorGomes, Ana M.
dc.contributor.authorPintado, Manuela
dc.contributor.authorCoelho, Marta C.
dc.date.accessioned2026-01-27T12:28:11Z
dc.date.available2026-01-27T12:28:11Z
dc.date.issued2026-01-20
dc.description.abstractBackground/Objectives: Carotenoids are bioactive pigments with well-established antioxidant and immunomodulatory properties, yet their impact on gut microbiota remains poorly understood from a chemical standpoint. This study explores how carotenoid structure and gastrointestinal stability shape microbial responses combining in vitro fermentation with bioinformatic analyses. Methods: Individual carotenoids (beta (?)-carotene, lutein, lycopene) and combined carotenoids, as well as algal-derived extracts were subjected to 48 h in vitro fermentation, and microbial composition and activity were assessed through sequencing and computational analysis. Results: ?-carotene and lycopene promoted acid-tolerant taxa such as Escherichia-Shigella, whereas lutein, due to its higher polarity, supported more transient fluctuations. Mixtures and algal carotenoids exhibited synergistic effects, sustaining beneficial genera including Bifidobacterium and Bacteroides and promoting structured ecological trajectories. Conclusions: These findings provide a chemistry-driven perspective on how carotenoids act as modulators of microbial ecosystems, with direct implications for the formulation of carotenoid-enriched functional foods and dietary interventions.eng
dc.identifier.citationRocha, H. R., Ribeiro, P., Rodrigues, P. M., & Gomes, A. M. et al. (2026). Bioinformatic insights into the carotenoids’ role in gut microbiota dynamics. Nutrients, 18(2), Article 330. https://doi.org/10.3390/nu18020330
dc.identifier.doi10.3390/nu18020330
dc.identifier.eid105028848845
dc.identifier.issn2072-6643
dc.identifier.other64cb39dd-defe-4315-91c8-2855a1a63602
dc.identifier.pmid41599943
dc.identifier.urihttp://hdl.handle.net/10400.14/56777
dc.identifier.wos001671108300001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCarotenoids
dc.subjectDietary antioxidants
dc.subjectFermentation dynamics
dc.subjectGut microbiota
dc.subjectHierarchical clustering
dc.subjectMetagenomic analysis
dc.subjectNutritional status
dc.subjectOxidative stress reduction
dc.subjectProvitamin A activity
dc.titleBioinformatic insights into the carotenoids’ role in gut microbiota dynamicseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.titleNutrients
oaire.citation.volume18
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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