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Fermentation of bioactive solid lipid nanoparticles by human gut microflora

2016-01Journal article Restricted access
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dc.contributor.authorMadureira, Ana Raquel
dc.contributor.authorCampos, Débora
dc.contributor.authorGullon, Beatriz
dc.contributor.authorMarques, Cláudia
dc.contributor.authorRodríguez-Alcalá, Luís M.
dc.contributor.authorCalhau, Conceição
dc.contributor.authorAlonso, Jose Luis
dc.contributor.authorSarmento, Bruno
dc.contributor.authorGomes, Ana M.
dc.contributor.authorPintado, M. E.
dc.date.accessioned2017-10-13T17:57:07Z
dc.date.available2017-10-13T17:57:07Z
dc.date.issued2016-01
dc.description.abstractSolid lipid nanoparticles (SLNs) can be used for oral delivery of phenolic compounds in order to protect them from the harsh conditions of digestion and improve their bioavailability in the intestinal epithelium. Recently, the production and characterization of SLNs loaded with rosmarinic acid (RA) and herbal extracts was performed for future use as functional food ingredients. Diet components have been shown to have a huge impact on gut microbiota viability and metabolic activity. Hence, SLNs loaded with RA, sage and savoury extracts have been evaluated for their effect on intestinal microbiota growth and the metabolic products generated. Fermentations in anaerobic batch cultures using volunteer human faeces were performed during 24 h. Dynamic bacterial population changes were analysed using PCR-real time, as well as the generation of fatty acids and the quantification of phenolic compounds by analytical methods. Solid lipid nanoparticles released phenolic compounds at non-inhibitory bacterial growth concentrations. Released herbal extract phenolic compounds showed a beneficial effect on gut microbiota growth (e.g. bifidogenic effects) and were used as substrates. Acetate, formate, lactate and butyrate were produced in higher concentrations. The released phenolic compounds also induced PUFA and trans fatty acids metabolic activity, the production of saturated fatty acids, as well of potential beneficial conjugated linoleic acid isomers. Solid lipid nanoparticles modulate gut microbiota and metabolic activities.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMADUREIRA, Ana Raquel; CAMPOS, Débora; GULLON, Beatriz; MARQUES, Cláudia; RODRÍGUEZ-ALCALÁ, Luís M.; CALHAU, Conceição; ALONSO, Jose Luis; SARMENTO, Bruno; GOMES, Ana M.; PINTADO, M. E. - Fermentation of bioactive solid lipid nanoparticles by human gut microflora. Food & Function. ISSN 2042-650X. Vol. 7, n.º 1 (2016), p. 516-529pt_PT
dc.identifier.doi10.1039/c5fo01004gpt_PT
dc.identifier.eid84956654905
dc.identifier.pmid26606879
dc.identifier.urihttp://hdl.handle.net/10400.14/23084
dc.identifier.wos000368860000052
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationStrategic Project - LA 16 - 2013-2014
dc.relationVINOFLAVO - Red wine flavonoids: bioavailability and biological properties.
dc.relationEVALUATION OF STABILITY AND TOXICITY OF NANOPARTICLES AS DELIVERY SYSTEMS OF BIOACTIVE SUBSTANCES IN DAIRY PRODUCTS
dc.subjectBacteriapt_PT
dc.subjectFecespt_PT
dc.subjectFermentationpt_PT
dc.subjectGastrointestinal Tractpt_PT
dc.subjectHumanspt_PT
dc.subjectLipidspt_PT
dc.subjectNanoparticlespt_PT
dc.subjectTriglyceridespt_PT
dc.subjectWaxespt_PT
dc.subjectLipid Metabolismpt_PT
dc.titleFermentation of bioactive solid lipid nanoparticles by human gut microflorapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 16 - 2013-2014
oaire.awardTitleVINOFLAVO - Red wine flavonoids: bioavailability and biological properties.
oaire.awardTitleEVALUATION OF STABILITY AND TOXICITY OF NANOPARTICLES AS DELIVERY SYSTEMS OF BIOACTIVE SUBSTANCES IN DAIRY PRODUCTS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAGR-ALI%2F117808%2F2010/PT
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oaire.citation.endPage529
oaire.citation.startPage516
oaire.citation.titleFood and Functionpt_PT
oaire.citation.volume7
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oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamCOMPETE
oaire.fundingStreamFARH
oaire.fundingStreamSFRH
person.familyNameMadureira
person.familyNameCampos
person.familyNameGullón Estévez
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person.givenNameRaquel
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person.givenNameBeatriz
person.givenNameCláudia
person.givenNameLuis Miguel
person.givenNameConceição
person.givenNameBruno
person.givenNameAna Maria
person.givenNameMaria Manuela
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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