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Effect of chronic consumption of blackberry extract on high-fat induced obesity in rats and its correlation with metabolic and brain outcomes

2016-01Journal article Restricted access
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dc.contributor.authorMeireles, Manuela
dc.contributor.authorRodríguez-Alcalá, Luís M
dc.contributor.authorMarques, Cláudia
dc.contributor.authorNorberto, Sónia
dc.contributor.authorFreitas, Joana
dc.contributor.authorFernandes, Iva
dc.contributor.authorMateus, Nuno
dc.contributor.authorGomes, Ana Maria
dc.contributor.authorFaria, Ana
dc.contributor.authorCalhau, Conceição
dc.date.accessioned2017-10-13T18:50:17Z
dc.date.available2017-10-13T18:50:17Z
dc.date.issued2016-01
dc.description.abstractFlavonoids have been presented as potential protectors against metabolic and cognitive dysfunction. However, mechanisms underlying these 'claims' have not been sufficiently explored. To analyse the effect of long-term supplementation with blackberry extract (BE) in the context of a high-fat or a standard diet, Wistar rats were divided into 4 groups (n = 6) fed with a standard or a high-fat diet, with or without BE supplementation at 25 mg per kg body weight per day. A high-fat diet significantly impaired glucose tolerance and increased body weight, caloric ingestion, very-low-density lipoprotein, triglycerides and cholesterol. Furthermore, it was observed that a high-fat diet increased dopamine content in the prefrontal cortex and decreased brain derived neurotrophic factor (BDNF) levels both in the prefrontal cortex and in plasma. BE supplementation only affected some of these aspects. BE slightly improved glucose metabolism and significantly decreased levels of lactate, independent of diet. BE decreased levels of BDNF and also interacted with the dopaminergic system, increasing dopamine turnover in the striatum, and reverting dopamine content induced by a high-fat diet in the prefrontal cortex. This study shows that, despite some particular benefits of anthocyanin supplementation, some long-term effects may not be desirable and further studies are needed to optimize ingestion conditions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMEIRELES, Manuela; RODRÍGUEZ-ALCALÁ, Luís M.; MARQUES, Cláudia; NORBERTO, Sónia; FREITAS, Joana; FERNANDES, Iva; MATEUS, Nuno; GOMES, Ana M.; FARIA, Ana; CALHAU, Conceição - Effect of chronic consumption of blackberry extract on high-fat induced obesity in rats and its correlation with metabolic and brain outcomes. Food & Function. ISSN 2042-650X. Vol. 7, n.º 1 (2016), p. 127-139pt_PT
dc.identifier.doi10.1039/c5fo00925apt_PT
dc.identifier.eid84956688153
dc.identifier.pmid26462860
dc.identifier.urihttp://hdl.handle.net/10400.14/23088
dc.identifier.wos000368860000012
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationSFRH/BPD/ 86173/2012pt_PT
dc.relationBIODISPONIBILIDADE DE FLAVONÓIDES: TRANSPORTE ATRAVÉS DA BARREIRA HEMO-ENCEFÁLICA E POTENCIAL NEURO-PROTECTOR. MODULAÇÃO NUTRICIONAL E FARMACOLÓGICA
dc.titleEffect of chronic consumption of blackberry extract on high-fat induced obesity in rats and its correlation with metabolic and brain outcomespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBIODISPONIBILIDADE DE FLAVONÓIDES: TRANSPORTE ATRAVÉS DA BARREIRA HEMO-ENCEFÁLICA E POTENCIAL NEURO-PROTECTOR. MODULAÇÃO NUTRICIONAL E FARMACOLÓGICA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FAGR-TEC%2F2227%2F2012/PT
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oaire.citation.endPage139
oaire.citation.startPage127
oaire.citation.titleFood and Functionpt_PT
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person.familyNameMeireles
person.familyNameRodríguez-Alcalá
person.familyNameMarques
person.familyNameFernandes
person.familyNameMateus
person.familyNameGomes
person.familyNameFaria
person.familyNameCalhau
person.givenNameManuela
person.givenNameLuis Miguel
person.givenNameCláudia
person.givenNameIva
person.givenNameNuno
person.givenNameAna Maria
person.givenNameAna
person.givenNameConceição
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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