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Chitosan in oral health: a proof of concept

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dc.contributor.authorCosta, E. M.
dc.contributor.authorSilva, Sara
dc.contributor.authorCardelle-Cobas, A.
dc.contributor.authorMadureira, A. R.
dc.contributor.authorFerreira, M. O.
dc.contributor.authorTavaria, Freni K.
dc.contributor.authorPintado, M. M.
dc.date.accessioned2014-05-15T12:10:24Z
dc.date.available2014-05-15T12:10:24Z
dc.date.issued2013
dc.description.abstractNowadays chitosan has established itself as a high sought material due to its biocompatibility, reduced toxicity and highpercentage of amino groups that confer it specific functionalities, including antimicrobial activity and acceleration of woundhealing, and studies into chitosan’s applicability have shown chitosan’s potential and feasibility. One of the possible fieldsof application for chitosan based products is the oral cavity, since several of the existing oral health products possesssecondary effects. The aim of this work was to prove that chitosan is a feasible component for oral health productsbiofabrication. As such a chitosan based mouthwash was developed and validated through assessment ofin vitroandin vivoantimicrobial activity, antibiofilm activity and sensory properties. The results obtained showed that it was possible tosuccessfully incorporate chitosan in an oral care product while retaining a considerable antimicrobial activity.In vitrotestingdemonstrated that the chitosan mouthwash possessed a wide range of antimicrobial activity against oral pathogens andwas capable of inhibiting microbial adherence and biofilm formation. Direct comparison with two commercial mouthwashesshowed that the chitosan mouthwash possessed stronger activity than both reference samples.In vivotesting showedthat the chitosan mouthwash was very effective in reducing enterococci and streptococci bacterial counts up to 30 min.after rinsing. Overall, the present shows a successful development of a chitosan-based product and is a tangible proof ofconcept for future utilization of chitosan in oral health.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationCOSTA, E. M… [et al.] - Chitosan in oral health: A proof of concept. Journal of Chitin and Chitosan Science. ISSN 2328-7500. Vol. 1, N.º 3 (2013), p. 251–259por
dc.identifier.doi10.1166/jcc.2013.1035
dc.identifier.issn2328-7500
dc.identifier.urihttp://hdl.handle.net/10400.14/14430
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAmerican Scientific Publisherspor
dc.subjectMouthwashpor
dc.subjectOral Carepor
dc.subjectAntimicrobialpor
dc.subjectAntibiofilmpor
dc.subjectIn Vivo Antimicrobialpor
dc.titleChitosan in oral health: a proof of conceptpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.titleJournal of Chitin and Chitosan Science
oaire.citation.volume1
person.familyNameMadureira
person.familyNameFerreira
person.familyNameKekhasharú Tavaria
person.familyNamePintado
person.givenNameRaquel
person.givenNameMaria Teresa
person.givenNameFreni
person.givenNameMaria Manuela
person.identifierM-4659-2013
person.identifier456608
person.identifier.ciencia-id1C14-25F8-CC07
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0001-6596-1927
person.identifier.orcid0000-0002-8446-5600
person.identifier.orcid0000-0002-6273-6668
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridM-4659-2013
person.identifier.ridF-7731-2015
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id8384097900
person.identifier.scopus-author-id6602645613
person.identifier.scopus-author-id7004483898
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublicationa38c2c1d-cb24-475e-99ee-8f701a4f02da
relation.isAuthorOfPublicatione42f563a-5b1e-4586-b302-efabe7ce07da
relation.isAuthorOfPublicationba387c7d-27c9-4016-895c-b35597e91ebc
relation.isAuthorOfPublication.latestForDiscoveryba387c7d-27c9-4016-895c-b35597e91ebc

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