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3D printed Poly(ε-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: a comparative study on a composite preparation by melt blending or solvent casting techniques and the influence of bioceramic content on scaffold properties

2022-02-01Journal article Open access
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dc.contributor.authorBiscaia, Sara
dc.contributor.authorBranquinho, Mariana V.
dc.contributor.authorAlvites, Rui D.
dc.contributor.authorFonseca, Rita
dc.contributor.authorSousa, Ana Catarina
dc.contributor.authorPedrosa, Sílvia Santos
dc.contributor.authorCaseiro, Ana R.
dc.contributor.authorGuedes, Fernando
dc.contributor.authorPatrício, Tatiana
dc.contributor.authorViana, Tânia
dc.contributor.authorMateus, Artur
dc.contributor.authorMaurício, Ana C.
dc.contributor.authorAlves, Nuno
dc.date.accessioned2022-03-10T16:03:54Z
dc.date.available2022-03-10T16:03:54Z
dc.date.issued2022-02-01
dc.description.abstractBone tissue engineering has been developed in the past decades, with the engineering of bone substitutes on the vanguard of this regenerative approach. Polycaprolactone-based scaffolds are fairly applied for bone regeneration, and several composites have been incorporated so as to improve the scaffolds’ mechanical properties and tissue in-growth. In this study, hydroxyapatite is incorporated on polycaprolactone-based scaffolds at two different proportions, 80:20 and 60:40. Scaffolds are produced with two different blending methods, solvent casting and melt blending. The prepared composites are 3D printed through an extrusion-based technique and further investigated with regard to their chemical, thermal, morphological, and mechanical characteristics. In vitro cyto-compatibility and osteogenic differentiation was also assessed with human dental pulp stem/stromal cells. The results show the melt-blending-derived scaffolds to present more promising mechanical properties, along with the incorporation of hydroxyapatite. The latter is also related to an increase in osteogenic activity and promotion. Overall, this study suggests polycaprolactone/hydroxyapatite scaffolds to be promising candidates for bone tissue engineering, particularly when produced by the MB method.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijms23042318pt_PT
dc.identifier.eid85124899975
dc.identifier.issn1661-6596
dc.identifier.pmcPMC8880322
dc.identifier.pmid35216432
dc.identifier.urihttp://hdl.handle.net/10400.14/36986
dc.identifier.wos000829953000001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subject3D printingpt_PT
dc.subjectBone tissue engineeringpt_PT
dc.subjectCompositespt_PT
dc.subjectCytocompatibilitypt_PT
dc.subjectHydroxyapatitept_PT
dc.subjectMelt blendingpt_PT
dc.subjectPolycaprolactonept_PT
dc.subjectSolvent castingpt_PT
dc.title3D printed Poly(ε-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: a comparative study on a composite preparation by melt blending or solvent casting techniques and the influence of bioceramic content on scaffold propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume23pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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