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Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies

2013Journal article Open access
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dc.contributor.authorAlves, M. J.
dc.contributor.authorFerreira, I. C. F. R.
dc.contributor.authorFroufe, H. J. C.
dc.contributor.authorAbreu, Rui M. V.
dc.contributor.authorMartins, A.
dc.contributor.authorPintado, M.
dc.date.accessioned2014-05-08T13:35:24Z
dc.date.available2014-05-08T13:35:24Z
dc.date.issued2013
dc.description.abstractAim and Methods: Although the antimicrobial activity of extracts from several mushroom species has been reported, studies with the individual compounds present in that extracts are scarce. Herein, the antimicrobial activity of different phenolic compounds identified and quantified in mushroom species from all over the world was evaluated. Furthermore, a structure-activity relationship (SAR) analysis and molecular docking studies were performed, in order to provide insights into the mechanism of action of potential antimicrobial drugs for resistant micro-organisms. Results: 2,4-Dihydroxybenzoic and protocatechuic acids were the phenolic compounds with higher activity against the majority of Gram-negative and Gram-positive bacteria. Furthermore, phenolic compounds inhibited more MRSA than methicillin-susceptible Staphylococcus aureus. MRSA was inhibited by 2,4-dihydroxybenzoic, vanillic, syringic (MICs = 0.5 mg ml(-1)) and p-coumaric (MIC = 1 mg ml(-1)) acids, while these compounds at the same concentrations had no inhibitory effects against methicillin-susceptible Staph. aureus. Conclusions: The presence of carboxylic acid (COOH), two hydroxyl (OH) groups in para and ortho positions of the benzene ring and also a methoxyl (OCH3) group in the meta position seems to be important for anti-MRSA activity. Significance and Impact of the Study: Phenolic compounds could be used as antimicrobial agents, namely against some micro-organisms resistant to commercial antibiotics.por
dc.description.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.citationALVES, M.J. …[et al.] - Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies. Journal of Applied Microbiology. ISSN 1364-5072. Vol. 115, n.º 2 (2013), p. 346—357por
dc.identifier.doi10.1111/jam.12196
dc.identifier.eid84880594256
dc.identifier.eissn1365-2672
dc.identifier.issn1364-5072
dc.identifier.pmid23510516
dc.identifier.urihttp://hdl.handle.net/10400.14/14313
dc.identifier.wosWOS:000321894900003
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - LA 16 - 2011-2012
dc.rights.uriN/A
dc.subjectAntimicrobial activitypor
dc.subjectClinical isolatespor
dc.subjectDockingpor
dc.subjectSARpor
dc.subjectWild mushroomspor
dc.titleAntimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studiespor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.citation.endPage357
oaire.citation.issue2
oaire.citation.startPage346
oaire.citation.titleJournal of Applied Microbiology
oaire.citation.volume115
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAlves
person.familyNameFerreira
person.familyNameFroufe
person.familyNameAbreu
person.familyNameMartins
person.familyNamePintado
person.givenNameMaria José
person.givenNameIsabel
person.givenNameHugo
person.givenNameRui
person.givenNameAnabela
person.givenNameMaria Manuela
person.identifier144781
person.identifier350819
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person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0001-9997-8743
person.identifier.orcid0000-0002-7745-8015
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridM-6624-2016
person.identifier.ridE-8500-2013
person.identifier.ridG-5488-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id7003290613
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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