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Insights on sulfamethoxazole bio-transformation by environmental proteobacteria isolates

2018Journal article Restricted access
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dc.contributor.authorReis, Patrícia J. M.
dc.contributor.authorHomem, Vera
dc.contributor.authorAlves, Arminda
dc.contributor.authorVilar, Vítor J.P.
dc.contributor.authorManaia, Celia M.
dc.contributor.authorNunes, Olga C.
dc.date.accessioned2018-09-17T16:16:53Z
dc.date.available2018-09-17T16:16:53Z
dc.date.issued2018
dc.description.abstractAlthough sulfonamide residues are frequently reported as freshwaters contaminants, information on the ability of native bacteria to modify these synthetic antibiotics is scarce. Our purpose was to investigate the potential of bacteria from different aquatic environments to cleave or transform sulfamethoxazole (SMX) and infer on their ability to reduce the toxicity of this antibiotic. From a collection of about 100 Proteobacteria, 47 strains previously isolated from drinking water, surface water, and wastewater grew in the presence of 200 μMSMX, and were further studied. Out of these, 14 strains, mostly from mineral drinking water, transformed SMX into equimolar amounts of the lesser toxic derivative N4-acetyl-sulfamethoxazole. The highest percentage of SMX transformation was recorded for two strains affiliated to Pseudomonas mandelii. For P. mandelii McBPA4 higher SMX transformation rate and extent were observed in fed-batch (∼8 μMSMX/h, 81%) than in batch conditions (∼5 μMSMX/h, 25%), but similar specific transformation rates were found in both cultivation modes (∼20 μmolSMX/gcell dry weight/h), indicating the dependence of the process on the microbial load. These results evidence that the capacity to transform synthetic antibiotics may be common among bacteria and highlight the potential of environmental bacteria in attenuating the potential adverse effects of pollution with sulfonamides.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationReis, P.J.M., Homem, V., Alves, A., Vilar, V. J.P., Manaia, C. M., Nunes, O. C. (2018). Insights on sulfamethoxazole bio-transformation by environmental Proteobacteria isolates. Journal of Hazardous Materials, 358, 310-318pt_PT
dc.identifier.doi10.1016/j.jhazmat.2018.07.012pt_PT
dc.identifier.eid85049480583
dc.identifier.eissn1873-3336
dc.identifier.issn0304-3894
dc.identifier.pmid29990819
dc.identifier.urihttp://hdl.handle.net/10400.14/25697
dc.identifier.wos000442334400034
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPOCI-01-0145-FEDER-006939pt_PT
dc.relationPOCI-01-0145-FEDER-006984pt_PT
dc.relationNORTE‐01‐0145‐FEDER‐000005pt_PT
dc.relationIF/00273/2013pt_PT
dc.subjectSulfonamidespt_PT
dc.subjectN4-acetylsulfamethoxazolept_PT
dc.subjectKinetic parameterspt_PT
dc.subjectMineral water isolatespt_PT
dc.subjectFed-batch cultivationpt_PT
dc.subjectSul genespt_PT
dc.titleInsights on sulfamethoxazole bio-transformation by environmental proteobacteria isolatespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FEQU%2F00511%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F80834%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F76974%2F2011/PT
oaire.citation.endPage318
oaire.citation.startPage310
oaire.citation.titleJournal of Hazardous Materialspt_PT
oaire.citation.volume358
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameReis
person.familyNameHomem
person.familyNameAlves
person.familyNameVilar
person.familyNameManaia
person.familyNameNunes
person.givenNamePatricia
person.givenNameVera
person.givenNameArminda
person.givenNameVítor
person.givenNameCélia
person.givenNameOlga
person.identifier.ciencia-id4513-42A0-CA64
person.identifier.ciencia-id951A-E736-A7A3
person.identifier.ciencia-idC31F-553B-6365
person.identifier.ciencia-idBA14-BD30-C9AF
person.identifier.orcid0000-0002-8106-8474
person.identifier.orcid0000-0002-3955-9042
person.identifier.orcid0000-0002-5090-621X
person.identifier.orcid0000-0003-0943-2144
person.identifier.orcid0000-0002-3674-1789
person.identifier.orcid0000-0003-4742-2537
person.identifier.ridM-4719-2013
person.identifier.scopus-author-id13104955700
person.identifier.scopus-author-id6507349900
person.identifier.scopus-author-id10540195800
person.identifier.scopus-author-id6602465318
person.identifier.scopus-author-id7005088596
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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