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Shifting patterns of dengue three years after Zika virus emergence in Brazil

2024-12Journal article Open access
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dc.contributor.authorPinotti, Francesco
dc.contributor.authorGiovanetti, Marta
dc.contributor.authorLima, Maricelia Maia de
dc.contributor.authorCerqueira, Erenilde Marques de
dc.contributor.authorAlcantara, Luiz C. J.
dc.contributor.authorGupta, Sunetra
dc.contributor.authorRecker, Mario
dc.contributor.authorLourenço, José
dc.date.accessioned2024-02-14T10:22:14Z
dc.date.available2024-02-14T10:22:14Z
dc.date.issued2024-12
dc.description.abstractIn 2015, the Zika virus (ZIKV) emerged in Brazil, leading to widespread outbreaks in Latin America. Following this, many countries in these regions reported a significant drop in the circulation of dengue virus (DENV), which resurged in 2018-2019. We examine age-specific incidence data to investigate changes in DENV epidemiology before and after the emergence of ZIKV. We observe that incidence of DENV was concentrated in younger individuals during resurgence compared to 2013-2015. This trend was more pronounced in Brazilian states that had experienced larger ZIKV outbreaks. Using a mathematical model, we show that ZIKV-induced cross-protection alone, often invoked to explain DENV decline across Latin America, cannot explain the observed age-shift without also assuming some form of disease enhancement. Our results suggest that a sudden accumulation of population-level immunity to ZIKV could suppress DENV and reduce the mean age of DENV incidence via both protective and disease-enhancing interactions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1038/s41467-024-44799-xpt_PT
dc.identifier.eid85182694062
dc.identifier.issn2041-1723
dc.identifier.pmcPMC10799945
dc.identifier.pmid38245500
dc.identifier.urihttp://hdl.handle.net/10400.14/43943
dc.identifier.wos001146298600008
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleShifting patterns of dengue three years after Zika virus emergence in Brazilpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleNature Communicationspt_PT
oaire.citation.volume15pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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