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Microfluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplements

dc.contributor.authorPereira, Mafalda G.
dc.contributor.authorMachado, Ana
dc.contributor.authorLeite, Andreia
dc.contributor.authorRangel, Maria
dc.contributor.authorBordalo, Adriano
dc.contributor.authorRangel, António O. S. S.
dc.contributor.authorMesquita, Raquel B. R.
dc.date.accessioned2024-02-16T11:13:09Z
dc.date.available2024-02-16T11:13:09Z
dc.date.issued2024-02-05
dc.description.abstractIodine is an essential micronutrient for humans due to its fundamental role in the biosynthesis of thyroid hormones. As a key parameter to assess health conditions, iodine intake needs to be monitored to ascertain and prevent iodine deficiency. Iodine is available from various food sources (such as seaweed, fish, and seafood, among others) and dietary supplements (multivitamins or mineral supplements). In this work, a microfluidic paper-based analytical device (μPAD) to quantify iodide in seaweed and dietary supplements is described. The developed μPAD is a small microfluidic device that emerges as quite relevant in terms of its analytical capacity. The quantification of iodide is based on the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by hydrogen peroxide in the presence of iodine, which acts as the catalyst to produce the blue form of TMB. Additionally, powder silica was used to intensify and uniformize the colour of the obtained product. Following optimization, the developed μPAD enabled iodide quantification within the range of 10–100 μM, with a detection limit of 3 μM, and was successfully applied to seaweeds and dietary supplements. The device represents a valuable tool for point-of-care analysis, can be used by untrained personnel at home, and is easily disposable, low-cost, and user-friendly.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/s24031024pt_PT
dc.identifier.eid85184667884
dc.identifier.issn1424-3210
dc.identifier.pmid38339741
dc.identifier.urihttp://hdl.handle.net/10400.14/43995
dc.identifier.wos001161014300001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIodide determinationpt_PT
dc.subjectµPADpt_PT
dc.subjectTMB reactionpt_PT
dc.subjectFood samplespt_PT
dc.subjectDietary supplementspt_PT
dc.titleMicrofluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplementspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.titleSensorspt_PT
oaire.citation.volume24pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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