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Development of a low pressure chromatographic flow system for monitoring the biodegradation of ofloxacin and ciprofloxacin

2016Journal article Restricted access
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dc.contributor.authorSantos, Inês C.
dc.contributor.authorMesquita, Raquel B. R.
dc.contributor.authorAmorim, Catarina L.
dc.contributor.authorCastro, Paula M. L.
dc.contributor.authorRangel, António O. S. S.
dc.date.accessioned2016-07-25T13:30:29Z
dc.date.available2016-07-25T13:30:29Z
dc.date.issued2016
dc.description.abstractIn this work, we propose a simple low pressure chromatography method with a high throughput for monitoring the biodegradation of fluoroquinolones. Fluoroquinolones are a class of antibiotics that have been accumulating in the environment as a consequence of their release from different sources, namely hospital waste. It has been found that wastewater treatment plants are not able to completely remove this type of micro-pollutants and so, alternative solutions are necessary. Some biodegradation studies have been done but the HPLC-based methodologies used to monitor the degradation process usually require high cost instrumentation such as analytical columns and detectors. For this reason, a 1 cm monolithic column was coupled to a flow injection system and used for the simultaneous quantification of ofloxacin and ciprofloxacin with UV detection at 295 and 275 nm, respectively. LODs of 0.5 and 0.29 mg L-1 for ofloxacin and ciprofloxacin were obtained, respectively, with repeatability within the range of 2–10%. The developed method was successfully applied to monitor the biodegradation of ofloxacin and ciprofloxacin by the strain Labrys portucalensis F11. The results proved that the low pressure chromatography method is a simpler, cheaper, and faster alternative to monitor biodegradation studies.pt_PT
dc.identifier.citationSANTOS, Inês C.; MESQUITA, Raquel B. R.; AMORIM, Catarina L.; CASTRO, Paula M. L.; RANGEL, António O. S. S. - Development of a low pressure chromatographic flow system for monitoring the biodegradation of ofloxacin and ciprofloxacin. Analytical Methods. ISSN 1364-5528. (2016) vol. 27, nº8, 5457-5465pt_PT
dc.identifier.doi10.1039/c6ay00476hpt_PT
dc.identifier.eid84978141531
dc.identifier.urihttp://hdl.handle.net/10400.14/20385
dc.identifier.wos000379480200015
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Royal Society of Chemistrypt_PT
dc.relationDEVELOPMENT OF AUTOMATIC MICROFLOW SYSTEMS FOR MONITORING MICROBIOGICAL, BIOCHEMICAL AND PHYSICO-CHEMICAL PARAMETERS IN BATHING WATERS
dc.titleDevelopment of a low pressure chromatographic flow system for monitoring the biodegradation of ofloxacin and ciprofloxacinpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDEVELOPMENT OF AUTOMATIC MICROFLOW SYSTEMS FOR MONITORING MICROBIOGICAL, BIOCHEMICAL AND PHYSICO-CHEMICAL PARAMETERS IN BATHING WATERS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F76012%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F96481%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.citation.endPage5465
oaire.citation.issue8
oaire.citation.startPage5457
oaire.citation.titleAnalytical Methods
oaire.citation.volume27
oaire.fundingStreamSFRH
oaire.fundingStream5876
person.familyNameSantos
person.familyNameMesquita
person.familyNameAmorim
person.familyNameCastro
person.familyNameSantos Silva Rangel
person.givenNameInês
person.givenNameRaquel
person.givenNameCatarina L.
person.givenNamePaula
person.givenNameAntónio Osmaro
person.identifierJ-4630-2013
person.identifier1394766
person.identifier2013444
person.identifier.ciencia-idEB1D-DEE3-0B60
person.identifier.ciencia-id791E-5D42-9B68
person.identifier.ciencia-id7C1F-6C72-354A
person.identifier.ciencia-idD61D-7CFB-178A
person.identifier.orcid0000-0002-4609-7085
person.identifier.orcid0000-0001-7745-1860
person.identifier.orcid0000-0002-6756-552X
person.identifier.orcid0000-0001-8841-6606
person.identifier.orcid0000-0002-6486-8947
person.identifier.ridJ-4829-2013
person.identifier.ridJ-4630-2013
person.identifier.ridK-6091-2014
person.identifier.ridM-8241-2013
person.identifier.scopus-author-id36953321400
person.identifier.scopus-author-id7005556626
person.identifier.scopus-author-id36896692500
person.identifier.scopus-author-id7102781782
person.identifier.scopus-author-id7004827387
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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