Browsing by Author "Xue, Pei"
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- Associations between changes in habitual sleep duration and lower self-rated health among COVID-19 survivors: findings from a survey across 16 countries/regionsPublication . Matsui, Kentaro; Chung, Frances; Bjelajac, Adrijana Koscec; Merikanto, Ilona; Korman, Maria; Mota-Rolim, Sérgio; Cunha, Ana Suely; Bjorvatn, Bjørn; Xue, Pei; Benedict, Christian; Morin, Charles M.; Espie, Colin A.; Landtblom, Anne Marie; Penzel, Thomas; De Gennaro, Luigi; Holzinger, Brigitte; Hrubos-Strøm, Harald; Leger, Damien; Bolstad, Courtney J.; Nadorff, Michael R.; Plazzi, Giuseppe; Reis, Catia; Chan, Ngan Yin; Wing, Yun Kwok; Yordanova, Juliana; Dauvilliers, Yves; Partinen, Markku; Inoue, YuichiBackground: Self-rated health (SRH) is widely recognized as a clinically significant predictor of subsequent mortality risk. Although COVID-19 may impair SRH, this relationship has not been extensively examined. The present study aimed to examine the correlation between habitual sleep duration, changes in sleep duration after infection, and SRH in subjects who have experienced SARS-CoV-2 infection. Methods: Participants from 16 countries participated in the International COVID Sleep Study-II (ICOSS-II) online survey in 2021. A total of 10,794 of these participants were included in the analysis, including 1,509 COVID-19 individuals (who reported that they had tested positive for COVID-19). SRH was evaluated using a 0-100 linear visual analog scale. Habitual sleep durations of < 6 h and > 9 h were defined as short and long habitual sleep duration, respectively. Changes in habitual sleep duration after infection of ≤ -2 h and ≥ 1 h were defined as decreased or increased, respectively. Results: Participants with COVID-19 had lower SRH scores than non-infected participants, and those with more severe COVID-19 had a tendency towards even lower SRH scores. In a multivariate regression analysis of participants who had experienced COVID-19, both decreased and increased habitual sleep duration after infection were significantly associated with lower SRH after controlling for sleep quality (β = −0.056 and −0.058, respectively, both p < 0.05); however, associations between current short or long habitual sleep duration and SRH were negligible. Multinomial logistic regression analysis showed that decreased habitual sleep duration was significantly related to increased fatigue (odds ratio [OR] = 1.824, p < 0.01), shortness of breath (OR = 1.725, p < 0.05), diarrhea/nausea/vomiting (OR = 2.636, p < 0.01), and hallucinations (OR = 5.091, p < 0.05), while increased habitual sleep duration was significantly related to increased fatigue (OR = 1.900, p < 0.01). Conclusions: Changes in habitual sleep duration following SARS-CoV-2 infection were associated with lower SRH. Decreased or increased habitual sleep duration might have a bidirectional relation with post-COVID-19 symptoms. Further research is needed to better understand the mechanisms underlying these relationships for in order to improve SRH in individuals with COVID-19.
- Associations between obesity, a composite risk score for probable long COVID, and sleep problems in SARS-CoV-2 vaccinated individualsPublication . Xue, Pei; Merikanto, Ilona; Delale, Eva A.; Bjelajac, Adrijana; Yordanova, Juliana; Chan, Rachel N. Y.; Korman, Maria; Mota-Rolim, Sérgio A.; Landtblom, Anne Marie; Matsui, Kentaro; Reis, Catia; Penzel, Thomas; Inoue, Yuichi; Nadorff, Michael R.; Holzinger, Brigitte; Morin, Charles M.; Espie, Colin A.; Plazzi, Giuseppe; Gennaro, Luigi De; Chung, Frances; Bjorvatn, Bjørn; Wing, Yun Kwok; Dauvilliers, Yves; Partinen, Markku; Benedict, ChristianBackground: Preliminary data suggests that obesity might hasten the decline in mRNA vaccine-induced immunity against SARS-CoV-2. However, whether this renders individuals with obesity more susceptible to long COVID symptoms post-vaccination remains uncertain. Given sleep’s critical role in immunity, exploring the associations between obesity, probable long COVID symptoms, and sleep disturbances is essential. Methods: We analyzed data from a survey of 5919 adults aged 18 to 89, all of whom received two SARS-CoV-2 mRNA vaccinations. Participants were categorized into normal weight, overweight, and obesity groups based on ethnicity-specific BMI cutoffs. The probability of long COVID was evaluated using the Post-Acute Sequelae of SARS-CoV-2 (PASC) score, as our survey did not permit confirmation of acute SARS-CoV-2 infection through methods such as antibody testing. Additionally, sleep patterns were assessed through questionnaires. Results: Participants with obesity exhibited a significantly higher adjusted odds ratio (OR) of having a PASC score of 12 or higher, indicative of probable long COVID in our study, compared to those with normal weight (OR: 1.55, 95% CI: 1.05, 2.28). No significant difference was observed for overweight individuals (OR: 0.92 [95% CI: 0.63, 1.33]). Both obesity and probable long COVID were associated with increased odds of experiencing a heightened sleep burden, such as the presence of obstructive sleep apnea or insomnia (P < 0.001). However, no significant interaction between BMI and probable long COVID status was found. Conclusions: Even post-vaccination, individuals with obesity may encounter a heightened risk of experiencing prolonged COVID-19 symptoms. However, confirming our observations necessitates comprehensive studies incorporating rigorous COVID infection testing, such as antibody assays - unavailable in our anonymous survey. Additionally, it is noteworthy that the correlation between probable long COVID and sleep disturbances appears to be independent of BMI.
- Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individualsPublication . Xue, Pei; Merikanto, Ilona; Chung, Frances; Morin, Charles M.; Espie, Colin; Bjorvatn, Bjørn; Cedernaes, Jonathan; Landtblom, Anne Marie; Penzel, Thomas; Gennaro, Luigi de; Holzinger, Brigitte; Matsui, Kentaro; Hrubos-Strøm, Harald; Korman, Maria; Leger, Damien; Mota-Rolim, Sérgio; Bolstad, Courtney J.; Nadorff, Michael; Plazzi, Giuseppe; Reis, Cátia; Chan, Rachel Ngan Yin; Wing, Yun Kwok; Yordanova, Juliana; Bjelajac, Adrijana Koscec; Inoue, Yuichi; Partinen, Markku; Dauvilliers, Yves; Benedict, ChristianShort nighttime sleep duration impairs the immune response to virus vaccination, and long nighttime sleep duration is associated with poor health status. Thus, we hypothesized that short (<6 h) and long (>9 h) nighttime sleepers have a higher post-COVID risk than normal nighttime sleepers, despite two doses of mRNA vaccine (which has previously been linked to lower odds of long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core COVID-19 symptom for at least three months (e.g., shortness of breath). Multivariate logistic regression adjusting for age, sex, BMI, and other factors showed in 9717 respondents (age span 18–99) that two mRNA vaccinations lowered the risk of suffering from post-COVID by about 21% (p < 0.001). When restricting the analysis to double-vaccinated respondents (n = 5918), short and long sleepers exhibited a greater post-COVID risk than normal sleepers (adjusted OR [95%-CI], 1.56 [1.29, 1.88] and 1.87 [1.32, 2.66], respectively). Among respondents with persistent sleep duration patterns during the pandemic compared to before the pandemic, short but not long sleep duration was significantly associated with the post-COVID risk (adjusted OR [95%-CI], 1.59 [1.24, 2.03] and 1.18 [0.70, 1.97], respectively). No significant association between sleep duration and post-COVID symptoms was observed in those reporting positive SARS-CoV-2 test results (n = 538). Our findings suggest that two mRNA vaccinations against SARS-CoV-2 are associated with a lower post-COVID risk. However, this protection may be less pronounced among those sleeping less than 6 h per night. Our findings warrant replication in cohorts with individuals with confirmed SARS-CoV-2 infection.