Percorrer por autor "Manso, Dina"
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- Diagnosis and risk prevention of Covid 19 in homeless people in LisbonPublication . Figueiredo, Amélia Simões; Resende, Ana; Ferrito, Cândida; Deodato, Sérgio; Neves-Amado, João; Manso, Dina; Almeida, António; Feliciano, Amélia; Rosa, Nuno; Barros, MarleneBackground The study is part of a broader research project – Public Bathouse Nursing - dedicated to the study of vulnerable populations that use the Public Bathouse in the city of Lisbon [1]. When SARS-CoV-2 pandemic situation started, structures for homeless people, at that time counted as 3029, were reinforced in Lisbon city. These people do not manage health autonomously, thus requiring defnition of strategies for testing and early diagnosis, to promote isolation and quick endorsementto Portuguese National Health Service. The project was approved by the Health Ethics Committee of the Regional Health Administration of Lisbon and Tagus Valley (Opinion 2776/CES/2021). Materials and methods Tracking SARS-CoV-2 lab tests were performed to the people from Temporary Housing Centers, Social Emergency Housing Centers and to those who, being homeless, were identifed by street technical teams. Our objectives were the detection of SARS-CoV-2 in the homeless people using the Public Bathhouse of Alcântara and of 10 structures of Planning and Intervention Centers in homelessness, such as street teams, temporary emergency shelters and cafeterias, promoting early detection and adequate endorsement of positive cases. The process of collection of spittle was performed between November 29th,2021and February 7th, 2022. From the initial 455 samples collected, 59 were annulled, due to poor quality and quantity. An error of 3,6% was considered, with a confdence level of 95,0%, thus making viable samples n= 396. Results Those 396 tracked people revealed an incidence rate of the disease of 2%, while, during the same period, the whole country rounded 18%. A study carried out in the United States of America did not fnd statistically signifcant relevance between the values of the incidence of the disease COVID-19 among homeless and non-homeless [2]. On the other hand, a Danish study revealed that the homeless population seems not to have been afected by COVID-19 in the frst wave [3]. The positive cases of COVID-19 who were lodged temporarily in Social Emergency Housing Centers, were isolated there, upon indication of Regional and Local Authorities, that were properly informed. Positive cases of homelessness people identifed and tracked on the streets, were endorsed to the Rear Support Structure, to guarantee appropriate isolation and dignifed convalescence. Conclusions The conclusion was that the incidence rate of COVID-19 in homeless people is below general population in Portugal.
- Exploring the inflammatory profile of homelessness population: a comprehensive analysis of individuals in two temporary shelters in LisbonPublication . Gomes, Ana T. P. C.; Mendes, Karina; Ferrito, Cândida; Andrade, Filipa; Neves-Amado, João; Resende, Ana; Santos, Paulo; Manso, Dina; Almeida, António; Vollrath, Antónia; Lopes, Rafaela; Barros, Marlene; Rosa, Nuno; Figueiredo, Amélia SimõesBackground: Homeless people are continuously facing adverse living conditions as poor access to basic nutrition, hygiene conditions and healthcare services, being at increased risk of severe infectious diseases as HIV and hepatitis as well as cardiovascular diseases and mental disorders. The characterization of homeless people’s health is fundamental to identify their health care needs. Considering that the aforementioned diseases are associated with chronic inflammatory processes, the main goal of this study was to characterize the inflammatory profile of a homeless population through quantification in saliva of a panel of inflammatory cytokines. Methods: The inflammatory profile was assessed in 114 individuals residing in two temporary shelters located in Lisbon and that accepted to participated in the study. Inflammatory proteins were quantified using a Multiplex Immunoassay approach. Data analysis was performed using the GraphPad Prism software and statistical significance among the groups was assessed using the nonparametric Mann–Whitney test. Results: Even though some protein levels might be masked by drug treatment, data analysis showed high levels of INF-ϒ, IL-10 and TNF-α in the infectious disease group, critical cytokines for the immune response against viruses and bacteria. Also, cytokines like IL-1β and IL-6 were detected at statistically significant levels in the cardiovascular disease group and all cytokines included in this study were quantified in the mental disorders group. Conclusion: These findings may help the healthcare services in the evaluation of treatment efficacy and disease monitoring, and in the development of effective public healthcare strategies and policy interventions to improve quality of life of the homeless population.