Browsing by Author "Gennaro, Luigi De"
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- Associations between obesity, a composite risk score for probable long COVID, and sleep problems in SARS-CoV-2 vaccinated individualsPublication . Xue, Pei; Merikanto, Ilona; Delale, Eva A.; Bjelajac, Adrijana; Yordanova, Juliana; Chan, Rachel N. Y.; Korman, Maria; Mota-Rolim, Sérgio A.; Landtblom, Anne Marie; Matsui, Kentaro; Reis, Catia; Penzel, Thomas; Inoue, Yuichi; Nadorff, Michael R.; Holzinger, Brigitte; Morin, Charles M.; Espie, Colin A.; Plazzi, Giuseppe; Gennaro, Luigi De; Chung, Frances; Bjorvatn, Bjørn; Wing, Yun Kwok; Dauvilliers, Yves; Partinen, Markku; Benedict, ChristianBackground: Preliminary data suggests that obesity might hasten the decline in mRNA vaccine-induced immunity against SARS-CoV-2. However, whether this renders individuals with obesity more susceptible to long COVID symptoms post-vaccination remains uncertain. Given sleep’s critical role in immunity, exploring the associations between obesity, probable long COVID symptoms, and sleep disturbances is essential. Methods: We analyzed data from a survey of 5919 adults aged 18 to 89, all of whom received two SARS-CoV-2 mRNA vaccinations. Participants were categorized into normal weight, overweight, and obesity groups based on ethnicity-specific BMI cutoffs. The probability of long COVID was evaluated using the Post-Acute Sequelae of SARS-CoV-2 (PASC) score, as our survey did not permit confirmation of acute SARS-CoV-2 infection through methods such as antibody testing. Additionally, sleep patterns were assessed through questionnaires. Results: Participants with obesity exhibited a significantly higher adjusted odds ratio (OR) of having a PASC score of 12 or higher, indicative of probable long COVID in our study, compared to those with normal weight (OR: 1.55, 95% CI: 1.05, 2.28). No significant difference was observed for overweight individuals (OR: 0.92 [95% CI: 0.63, 1.33]). Both obesity and probable long COVID were associated with increased odds of experiencing a heightened sleep burden, such as the presence of obstructive sleep apnea or insomnia (P < 0.001). However, no significant interaction between BMI and probable long COVID status was found. Conclusions: Even post-vaccination, individuals with obesity may encounter a heightened risk of experiencing prolonged COVID-19 symptoms. However, confirming our observations necessitates comprehensive studies incorporating rigorous COVID infection testing, such as antibody assays - unavailable in our anonymous survey. Additionally, it is noteworthy that the correlation between probable long COVID and sleep disturbances appears to be independent of BMI.
- Estimation bias and agreement limits between two common self-report methods of habitual sleep duration in epidemiological surveysPublication . Korman, Maria; Zarina, Daria; Tkachev, Vadim; Merikanto, Ilona; Bjorvatn, Bjørn; Bjelajac, Adrijana Koscec; Penzel, Thomas; Landtblom, Anne Marie; Benedict, Christian; Chan, Ngan Yin; Wing, Yun Kwok; Dauvilliers, Yves; Morin, Charles M.; Matsui, Kentaro; Nadorff, Michael; Bolstad, Courtney J.; Chung, Frances; Mota-Rolim, Sérgio; Gennaro, Luigi De; Plazzi, Giuseppe; Yordanova, Juliana; Holzinger, Brigitte; Partinen, Markku; Reis, CátiaAccurate measurement of habitual sleep duration (HSD) is crucial for understanding the relationship between sleep and health. This study aimed to assess the bias and agreement limits between two commonly used short HSD self-report methods, considering sleep quality (SQ) and social jetlag (SJL) as potential predictors of bias. Data from 10,268 participants in the International COVID Sleep Study-II (ICOSS-II) were used. Method-Self and Method-MCTQ were compared. Method-Self involved a single question about average nightly sleep duration (HSDself), while Method-MCTQ estimated HSD from reported sleep times on workdays (HSDMCTQwork) and free days (HSDMCTQfree). Sleep quality was evaluated using a Likert scale and the Insomnia Severity Index (ISI) to explore its influence on estimation bias. HSDself was on average 42.41 ± 67.42 min lower than HSDMCTQweek, with an agreement range within ± 133 min. The bias and agreement range between methods increased with poorer SQ. HSDMCTQwork showed less bias and better agreement with HSDself compared to HSDMCTQfree. Sleep duration irregularity was − 43.35 ± 78.26 min on average. Subjective sleep quality predicted a significant proportion of variance in HSDself and estimation bias. The two methods showed very poor agreement and a significant systematic bias, both worsening with poorer SQ. Method-MCTQ considered sleep intervals without adjusting for SQ issues such as wakefulness after sleep onset but accounted for sleep irregularity and sleeping in on free days, while Method-Self reflected respondents’ interpretation of their sleep, focusing on their sleep on workdays. Including an SQ-related question in surveys may help bidirectionally adjust the possible bias and enhance the accuracy of sleep-health studies.