Browsing by Author "Chadli, Noureddine"
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- Effect of phenolic compounds extracted from turmeric (Curcuma longa L.) and ginger (Zingiber officinale) on cutaneous wound healing in wistar ratsPublication . Bouchama, Chaymae; Zinedine, Abdellah; Rocha, João Miguel; Chadli, Noureddine; El Ghadraoui, Lahsen; Chabir, Rachida; Raoui, Sidi Mohammed; Errachidi, FaouziTurmeric and ginger, widely used rhizomes in culinary arts, have several beneficial biological activities, such as hypoglycemic, hepato-protective, antimicrobial, and antioxidant properties. This work investigated the effects of three phenolic extracts isolated from turmeric and ginger rhizomes on anti-inflammatory and healing properties using the solid–liquid extraction method. Wistar rats were used as a biological model. The anti-inflammatory activity was evaluated on induced edema in the rat’s hind paw using carrageenan (1%). Paw volume was measured at 0 min, 45 min, 3 h, and 5 h. Treatment with turmeric and ginger extracts, administered at a dose of 100 mg/kg, revealed a reduction in edema volume by 98.8%, 94.8%, and 98.3% using an aqueous extract of turmeric, ethanolic extract of turmeric, and methanolic extract of ginger, respectively. The healing activity parameters of induced burns on the rat’s dorsal region in nine groups (7 rats each) were monitored daily throughout the experiment’s duration. Results showed that the application of creams composed of petroleum jelly dispersing turmeric and ginger extracts to wounds at a dose of 100 mg/kg g induced complete healing after 19 days while the negative control was only 60% cured. On day 14, the aqueous, ethanolic, and methanolic turmeric extracts nearly resulted in complete tissue repair by 95.26%, 98.34%, and 87.39%, respectively. According to the chromatographic analysis (Sephadex G50 column), there is a variation in the molecular weight distribution of phenolic compounds (polymers, oligomers, and monomers) in the three studied extracts, which has a differential effect on the anti-inflammatory and wound healing activities of the extracts.
- Effect of powdered rosemary (Rosmarinus officinalis) essential oil and phenolic compounds on broiler chickens zootechnical parametersPublication . Samouh, Khaoula Filali; Zinedine, Abdellah; Rocha, João M.; Chadli, Noureddine; Raoui, Sidi M.; Errachidi, FaouziThis work aims at exploiting the essential oil (EO) and phenolic compounds (PC) of rosemary (Rosmarinus officinalis) in a formulation containing leaf powder stabilized with chitin (1%, w/w) to improve chicken meat and investigate their effect on qualitatively and quantitatively broiler chickens’ growth performances. To such a purpose, chicks, at 1 day of age, were distributed in pens on ground divided into four batches. The two control batches were fed with conventional feed, but the positive control contained flavomycin (0.5 g/kg) as growth factor. The two treated batches received a conventional feed supplemented with two doses of 20 and 50 g/kg of the developed formulation. Essential oil and phenolic compound contents in powdered leaves were, respectively, 1.20 and 22.86% in ethanolic extract. 1,8-Cineole (46.88%), followed by camphor (19.20%), α-pinene (9.56%), L.α.-terpineol (5.91%) and β-pinene (4.40%) were the main compounds of the used EO. The two batches of treated chicks showed a significant improvement in body weight (281.88 and 283.75 g, respectively), a decrease in feed conversion and a reduction in mortality (8%), when compared to the control batches. In addition, the elaborated formulation induced catalase activity used as an indicator of cellular antioxidant activity modulation.