Browsing by Author "Castro, Emerson"
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- Genomic and eco-epidemiological investigations in Uruguay reveal local Chikungunya virus transmission dynamics during its expansion across the Americas in 2023Publication . Burgueño, Analía; Giovanetti, Marta; Fonseca, Vagner; Morel, Noelia; Lima, Mauricio; Castro, Emerson; Guimarães, Natália R.; Iani, Felipe C. M.; Bormida, Victoria; Cortinas, Maria Noel; Ramas, Viviana; Coppola, Leticia; Bento, Ana I.; Franco, Leticia; Rico, Jairo Mendez; Lourenço, José; Alcantara, Luiz Carlos Junior; Chiparelli, HectorUruguay experienced its first Chikungunya virus outbreak in 2023, resulting in a significant burden to its healthcare system. We conducted analysis based on real-time genomic surveillance (30 novel whole genomes) to offer timely insights into recent local transmission dynamics and eco-epidemiological factors behind its emergence and spread in the country.
- Genomics-based timely detection of dengue virus type I genotypes I and V in UruguayPublication . Morel, Noelia; Giovanetti, Marta; Fonseca, Vagner; Burgueño, Analía; Lima, Mauricio; Castro, Emerson; Guimarães, Natália R.; Iani, Felipe C. M.; Bormida, Victoria; Cortinas, Maria Noel; Ramas, Viviana; Coppola, Leticia; Bento, Ana I.; Rosewell, Alexander; Franco, Leticia; Rico, Jairo Mendez; Lourenço, José; Alcantara, Luiz Carlos Junior; Chiparelli, HectorThis study details a genomics-based approach for the early detection of mosquito-borne pathogens, marked by Uruguay's first ever complete genomic sequencing of Dengue Virus type I genotypes I and V. This pioneering effort has facilitated the prompt identification of these genotypes within the country, enabling Uruguayan public health authorities to develop timely and effective response strategies. Further integrated into this approach is a climate-driven suitability measure, closely associated with Dengue case reports and indicative of the local climate's role in the virus's transmission in the country within the changing climate context. The detection of multiple DENV-1 genotypes co-circulating in Uruguay underscores the necessity for proactive surveillance, particularly at borders, to prevent the introduction and dissemination of novel viral strains within the country and the region. This approach aids in facilitating prompt public health responses and intervention strategies, which are crucial in mitigating the impact of dengue outbreaks.