Browsing by Author "Cardoso, Ana"
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- António Carneiro's painting collection from the municipality of Oporto. Study and conservation in the 150th anniversary of the painter's birthPublication . Barata, Carolina; Cabral, Ana; Aguiar, Maria; Castro, Laura; Machado, Ana; Cardoso, Ana; Valadas, Sara; Piorro, LuisThis paper presents a summary of the results obtained in the first approach ever made to the characterization of the materials and techniques used in the oil painting production by António Carneiro (1872–1930), one of the best portuguese painters in the transition from the 19th to the 20th centuries. A selection of ten oils on canvas belonging to the Municipality of Oporto were analysed using a set of non-invasive techniques: Infrared Reflectography, Ultraviolet Fluorescence Photography, X-ray Fluorescence Spectrometry, Fiber Optics Reflectance Spectroscopy and Fourier Transform Infrared Spectroscopy. The results obtained suggest the use of materials and techniques established in Europe at the turn of the century. The palette is composed of Pb, Zn, Hg, Cr, Cd, Cu, and Co-based pigments, associated with both traditional and recently introduced materials. The great missing element is Ti, associated with Titanium White, available on the market since 1918.
- Complex interactions between p.His558Arg and linked variants in the sodium voltage-gated channel alpha subunit 5 (NaV1.5)Publication . Lopes-Marques, Mónica; Silva, Raquel; Serrano, Catarina; Gomes, Verónica; Cardoso, Ana; Prata, Maria João; Amorim, António; Azevedo, LuísaCommon genetic polymorphisms may modify the phenotypic outcome when co-occurring with a disease-causing variant, and therefore understanding their modulating role in health and disease is of great importance. The polymorphic p.His558Arg variant of the sodium voltage-gated channel alpha subunit 5 (NaV1.5) encoded by the SCN5A gene is a case in point, as several studies have shown it can modify the clinical phenotype in a number of cardiac diseases. To evaluate the genetic backgrounds associated with this modulating effect, we reanalysed previous electrophysiological findings regarding the p.His558Arg variant and further assessed its patterns of genetic diversity in human populations. The NaV1.5 p.His558Arg variant was found to be in linkage disequilibrium with six other polymorphic variants that previously were also associated with cardiac traits in GWAS analyses. On account of this, incongruent reports that Arg558 allele can compensate, aggravate or have no effect on NaV1.5, likely might have arose due to a role of p.His558Arg depending on the additional linked variants. Altogether, these results indicate a major influence of the epistatic interactions between SCN5A variants, revealing also that phenotypic severity may depend on the polymorphic background associated to each individual genome.
- Mesiodentes: diagnóstico clínico e radiológicoPublication . Cardoso, Ana; Lima, T.; Morais, J.; Dias, R.; Borges, Tiago; Carvalho, A.