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Anti-inflammatory and antioxidant activity improvement of lycopene from guava on nanoemulsifying system

2021Artigo científico Acesso restrito
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dc.contributor.authorAmorim, Adriany
dc.contributor.authorSouza, Jéssica
dc.contributor.authorOliveira, Ana
dc.contributor.authorSantos, Raimunda
dc.contributor.authorVasconcelos, Andreanne
dc.contributor.authorAraújo, Thiago
dc.contributor.authorCabral, Wanessa
dc.contributor.authorSilva, Maria
dc.contributor.authorMafud, Ana
dc.contributor.authorMascarenhas, Yvonne
dc.contributor.authorMedeiros, Jand-Venes
dc.contributor.authorSaraiva, Jaco
dc.contributor.authorMuehlmann, Luis
dc.contributor.authorKückelhaus, Selma
dc.contributor.authorPintado, Manuela
dc.contributor.authorLeite, José R.
dc.date.accessioned2020-03-19T12:07:47Z
dc.date.available2020-03-19T12:07:47Z
dc.date.issued2021
dc.description.abstractThe nanoemulsion system can improve stability to antioxidant molecules when compared to the isolated molecule. Therefore, this study aimed to establish conditions on thermal stability, chemical characterization, antioxidant and anti-inflammatory activity of lycopene nanoemulsion. Different chemical assays were used to characterize the lycopene nanoemulsion (LN) and the purified lycopene from guava (LPG) as HPLC, UV-Vis, DLS, and ABTS to analyze the antioxidant activity of lycopene nanoemulsion. To test its thermal stability as an antioxidant in nanoemulsion it was used the thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) techniques. The carrageenan-induced paw edema model in Swiss mice and histopathological analysis were used to evaluate anti-inflammatory activity. Emulsion with a mean droplet size of z-Average diameter 167.1 d.nm was produced. UV-vis detected kmax ¼ 447.1, 473.7, and 505.3nm to lycopene from guava and HPLC-DAD analysis by C30 at 472nm identified the presence of lycopene in the nanoemulsion. This lycopene nanoemulsion presented thermal stability at room temperature, as well as on concentration when stored for one year. Also significantly inhibited (p<0.05) the edema formation, with maximum inhibitory effect at 50mg/kg by oral and intraperitoneal route and reduced neutrophil migration in paw tissue. The lycopene nanoemulsion can be a potential candidate for investigation and therapy of various diseases, including inflammation because this lycopene nanoemulsion presented therapeutics application for inflammatory diseases, and has also potential to be used as ointment and/or cream additive for topic applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAdriany, A., Jessica, S., Ana, O., Raimunda, S., Andreanne, V., Luan, S., Thiago, A., Wanessa, C., Maria, S., Ana, M., Yvonne, M., Jand-Venes, M., Jaco, S., Luis, M., Selma, K., Manuela, P., & Jose, R. L. (2020). Anti-inflammatory and antioxidant activity improvement of lycopene from guava on nanoemulsifying system. Journal of Dispersion Science and Technology, 42(5), 760-770. https://doi.org/10.1080/01932691.2020.1728300pt_PT
dc.identifier.doi10.1080/01932691.2020.1728300pt_PT
dc.identifier.eid85080975127
dc.identifier.eissn1532-2351
dc.identifier.issn0193-2691
dc.identifier.urihttp://hdl.handle.net/10400.14/30049
dc.identifier.wos000518270000001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relation2014/02282-6pt_PT
dc.relation165177/2014-4pt_PT
dc.relation1713871pt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectIycopenept_PT
dc.subjectNanoemulsionpt_PT
dc.subjectThermal behaviorpt_PT
dc.titleAnti-inflammatory and antioxidant activity improvement of lycopene from guava on nanoemulsifying systempt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F75041%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0016%2F2013/PT
oaire.citation.endPage770
oaire.citation.issue5
oaire.citation.startPage760
oaire.citation.titleJournal of Dispersion Science and Technologypt_PT
oaire.citation.volume42
oaire.fundingStreamSFRH
oaire.fundingStream3599-PPCDT
person.familyNameAMORIM
person.familyNameOliveira
person.familyNamePintado
person.givenNameADRIANY
person.givenNameAna
person.givenNameMaria Manuela
person.identifier1415634
person.identifier456608
person.identifier.ciencia-id4713-31C8-A356
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0002-1788-6069
person.identifier.orcid0000-0001-8012-4203
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridJ-3404-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55937245800
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd9473cec-6bd0-461a-9b50-9eb3f7104506
relation.isAuthorOfPublicationbc42fa97-aa34-428f-b73f-d4327706efec
relation.isAuthorOfPublicationba387c7d-27c9-4016-895c-b35597e91ebc
relation.isAuthorOfPublication.latestForDiscoverybc42fa97-aa34-428f-b73f-d4327706efec
relation.isProjectOfPublicatione0ce4436-5836-44f4-8052-aa8b9c54720c
relation.isProjectOfPublication76842dfa-b675-443a-843b-f9555a0a9199
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