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Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis

2025-06-01Research article Open access
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dc.contributor.authorSantos, André A.
dc.contributor.authorPires, David
dc.contributor.authorMarques, Vanda
dc.contributor.authorAlesina, Nicole
dc.contributor.authorHerraez, Elisa
dc.contributor.authorRoudnický, Pavel
dc.contributor.authorRodrigues, Pedro M.
dc.contributor.authorGodinho-Santos, Ana
dc.contributor.authorBravo, Ana Catarina
dc.contributor.authorGouveia, Catarina
dc.contributor.authorSaraiva, Susana
dc.contributor.authorCorreia, Luís
dc.contributor.authorCrespo, Ricardo
dc.contributor.authorSilva, João Pereira da
dc.contributor.authorCravo, Marília
dc.contributor.authorZdráhal, Zbyněk
dc.contributor.authorBanales, Jesus M.
dc.contributor.authorMarin, Jose J. G.
dc.contributor.authorTorres, Joana
dc.contributor.authorRodrigues, Cecília M. P.
dc.contributor.authorPotesil, David
dc.date.accessioned2025-09-02T13:40:17Z
dc.date.available2025-09-02T13:40:17Z
dc.date.issued2025-06-01
dc.description.abstractPrimary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with underlying inflammatory bowel disease (IBD). This study investigates how PSC predisposes individuals to altered inflammatory immune responses compared with IBD alone. A case–control study was conducted with a cohort of 75 patients, including 16 with PSC (14 with concomitant IBD), 39 with IBD alone, and 20 controls. Serum bile acid profile, proteomic analysis, and immune-related gene expression in the colon tissue were examined. Colonic tissue from PSC patients exhibited up-regulation of immune regulation and inflammatory signaling mRNA markers, including LGR5, IL-8, CCL2, COX2, TWIST1, and SNAIL. Additionally, PSC patients displayed a distinct proinflammatory serum proteomic signature and moderate elevation of some bile acids, such as glycochenodeoxycholic acid (GCDCA). Co-incubation of human-derived monocytes with GCDCA partially replicated the inflammatory profile observed in PSC. These findings suggest that circulating bile acids modulate the peripheral immune system proinflammatory response, contributing to the unique PSC phenotype.eng
dc.identifier.citationSantos, A. A., Pires, D., Marques, V., & Alesina, N. et al. (2025). Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis. Clinical Science, 139(12), 703-716. https://doi.org/10.1042/CS20256078
dc.identifier.doi10.1042/CS20256078
dc.identifier.eid105009824170
dc.identifier.issn0143-5221
dc.identifier.otherc4167b2d-6019-4740-a65b-f23d24368114
dc.identifier.pmid40476597
dc.identifier.urihttp://hdl.handle.net/10400.14/54606
dc.identifier.wos001530342300001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titlePrimary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitiseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage716
oaire.citation.issue12
oaire.citation.startPage703
oaire.citation.titleClinical Science
oaire.citation.volume139
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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