Silva, João CarlosPonte, AnaMota, MargaridaPinho, RolandoVieira, NunoOliveira, RosaMota-Carvalho, NelsonGomes, Ana CatarinaAfecto, EdgarCarvalho, João2021-01-292021-01-292020Silva, J. C., Ponte, A., Mota, M., Pinho, R., Vieira, N., Oliveira, R., ... Edgar, A. (2020). Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae. Revista Espanola de Enfermedades Digestivas, 112(12), 925-9281130-0108http://hdl.handle.net/10400.14/31815Background and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization. Results: out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks. Conclusion: FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.engFecal microbiota transplantationCarbapenamase-producing enterobacteriaceaeMultidrug-resistant infectionsDecolonizationIntestinal carriagejournal article10.17235/reed.2020.7150/20202340-41678509632878533118360000597214000006